左氧氟沙星与环丙沙星治疗泌尿系感染的成本-效果分析

Cost-effectiveness analysis of levofloxacin and ciprofloxacin in treatment of urinary tract infection

目的探讨左氧氟沙星与环丙沙星治疗泌尿系感染的临床疗效及经济效果。方法 86例泌尿系感染患者,按入院先后随机分为观察组与对照组各43例,观察组给予静脉滴注左氧氟沙星500mg,每天1次;对照组给予静脉滴注环丙沙星400mg,每天2次,连续给药7天为1疗程。对两组的临床疗效及医药费用进行比较分析。结果观察组的有效率为93.5%,对照组为91.3%,组间比较无显著性差异(P>0.05);观察组的总费用1292元;对照组为715元,组间比较具有显著性差异(P<0.05)。结论两种药物治疗泌尿系感染的疗效近似,但应用环丙沙星进行治疗更经济、更符合成本-效果药物经济学方案。

Objective To explore the clinical efficacy of levofloxacin and ciprofloxacin in the treatment of urinary tract infection and economic effects.Methods By order of admission,86 patients with urinary tract infection has randomly divided into observation group and control group（n=43 cases）.The observation group was treated with intravenous infusion of levofloxacin 500mg,qd;control group were given intravenous ciprofloxacin 400mg,bid.Continuous administration of 7 days for a course of treatment.The clinical efficacy and cost of medicines were analyzed.Results The efficiency of the observation group was 93.5% and 91.3% in the control group.The difference was not statistically significant between groups（P0.05）.The total cost of observation group was 1292 yuan while the control group was 715 yuan（P0.05）.Conclusion The efficacy of two drugs is similar in the treatment of urinary tract infection,but given ciprofloxacin treatment program is more economical.