摘要
制备了一种表面接枝聚(γ-苄基-L-谷氨酸)的改性纳米羟基磷灰石(PBLG-g-HA),利用红外光谱(FT-IR)、X射线光电子能谱(XPS)证明了聚(γ-苄基-L-谷氨酸)(PBLG)成功的接枝在羟基磷灰石表面,TGA结果显示PBLG的接枝量为33.6%。通过溶剂复合法制得了PBLG-g-HA/PLLA复合材料,并通过MTT法对所制备的复合材料的细胞毒性进行了研究。结果表明,PBLG-g-HA/PLLA复合材料具有良好的生物相容性、能够促进成骨细胞增殖。
A kind of poly(γ-benzyl-L-glutamate) modified hydroxyapatite was prepared.Fourier transform infrared(FT-IR) spectroscopy,X-ray photoelectron spectroscopy(XPS) showed that PBLG was successfully grafted.The thermal gravimetric analysis(TGA) results indicated that the surface grafting amount of PBLG-g-HA was about 33.6%.PBLG-g-HA/poly(L-lactide)(PLLA) nanocomosites were prepared via solvent-mixing method.Cell culture tests and MTT assessments showed that PBLG-g-HA/PLA composites possessed excellent biocompatibility and promote the adhesion and proliferation of osteoblast.
出处
《南昌大学学报(理科版)》
CAS
北大核心
2012年第4期359-362,共4页
Journal of Nanchang University(Natural Science)
基金
江西省自然科学基金资助项目(20114BAB213009)
关键词
羟基磷灰石
表面改性
聚乳酸
复合材料
细胞毒性
hydroxyapatite
surface modification
poly(L-lactide)
composites
cytotoxicity