期刊文献+

改性羟基磷灰石/聚乳酸(PLLA)复合材料的制备及细胞毒性 被引量:4

Preparation and cytotoxicity of modified hydroxyapatite/Poly(L-lactide) composites
下载PDF
导出
摘要 制备了一种表面接枝聚(γ-苄基-L-谷氨酸)的改性纳米羟基磷灰石(PBLG-g-HA),利用红外光谱(FT-IR)、X射线光电子能谱(XPS)证明了聚(γ-苄基-L-谷氨酸)(PBLG)成功的接枝在羟基磷灰石表面,TGA结果显示PBLG的接枝量为33.6%。通过溶剂复合法制得了PBLG-g-HA/PLLA复合材料,并通过MTT法对所制备的复合材料的细胞毒性进行了研究。结果表明,PBLG-g-HA/PLLA复合材料具有良好的生物相容性、能够促进成骨细胞增殖。 A kind of poly(γ-benzyl-L-glutamate) modified hydroxyapatite was prepared.Fourier transform infrared(FT-IR) spectroscopy,X-ray photoelectron spectroscopy(XPS) showed that PBLG was successfully grafted.The thermal gravimetric analysis(TGA) results indicated that the surface grafting amount of PBLG-g-HA was about 33.6%.PBLG-g-HA/poly(L-lactide)(PLLA) nanocomosites were prepared via solvent-mixing method.Cell culture tests and MTT assessments showed that PBLG-g-HA/PLA composites possessed excellent biocompatibility and promote the adhesion and proliferation of osteoblast.
机构地区 南昌大学化学系
出处 《南昌大学学报(理科版)》 CAS 北大核心 2012年第4期359-362,共4页 Journal of Nanchang University(Natural Science)
基金 江西省自然科学基金资助项目(20114BAB213009)
关键词 羟基磷灰石 表面改性 聚乳酸 复合材料 细胞毒性 hydroxyapatite surface modification poly(L-lactide) composites cytotoxicity
  • 相关文献

参考文献8

  • 1HARTGERINK J D, BENIASH E, STUPP S I. SelfAssembly and Mineralization of Peptide-Amphiphile Nanofibers[J]. Science,2001,294 (5547): 1684-1688.
  • 2LOO S C J,MOORE T,BANIK B, et al. Biomedical Applications of Hydroxyapatite Nanoparticles [J]. Current Pharmaceutical Biotechnology,2010,11 (4) :333-342.
  • 3DUCHEYNE P, QIU Q, Bioactive Ceramics : the Effect of Surface Reactivity on Bone Formation and Bone Cell function[J]. Biomaterials, 1999,20: 2287-2303.
  • 4ZHANG C Y, CHEN J, ZHUANG Z, et al. In Situ Hybridization and Characterization of Fibrous Hydroxyapatite/chitosan Nanocomposite[J]. Journal of Applied Polymer Science, 2012,124 : 397-402.
  • 5CHANG J H,PARK M E,SHIN Y,et al. Functional Scaffolds of Bicontinuous,Thermoresponsive L3-phase Silica/hydroxyapatite Nanocomposites[J]. Journal of Materials Chemistry, 2007,17 (3) : 238-242.
  • 6HONG Z,ZHANG P, HE C, et al. Nano-composite of Poly(L-lactide) and Surface Grafted Hydroxyapatite: Mechanical Properties and Biocompatibility[J]. Biomaterials, 2005,26 (32) : 6296-6304.
  • 7ZHANG P, HONG Z, YU T, et al. In Vivo Mineralization and Osteogenesis of Nanocomposite Scaffold of Poly (lactide-co-glycolide) and Hydroxyapatite Sur- face-grafted with Poly (L-lactide) [J]. Biomaterials, 2009,30 (1) : 58-70.
  • 8WEI J,LIU A,CHEN L, et al. The Surface Modifica- tion of Hydroxyapatite Nanoparticles by the Ring O- pening Polymerization of 2'-benzyl-L-glutamate N-car-boxyanhydride[J]. Macromolecular Bioscience, 2009, 9:631-638.

同被引文献51

  • 1韩长菊,陈庆华,杨喜昆,叶金凤,高伟.纳米羟基磷灰石/胶原蛋白复合支架材料的制备与性能研究[J].材料导报,2007,21(9):139-141. 被引量:7
  • 2ITAKA K,ISHII T, HASEGAWA Y, et al. Biodegrad- able Polyamino Acid-Based Polycations as Safe and Ef- fective Gene Carrier Minimizing Cumulative Toxicity [J]. Biomaterials, 2010,31 : 3707-3714.
  • 3MARKLAND PoAMIDON G L,YANG V C. Modified Polypeptides Containing Gamma-Benzyl Glutamic Acid as Drug Delivery Platforms[J]. International Journal of Pharmaceutics, 1999,178 : 183-92.
  • 4HARNET J C,LE Guen E,BALL V,et al. Antibacte- rial Protection of Suture Material by Chlorhexidine- Functionalized Polyelectrolyte Multilayer Films, 2009, 20:185-193.
  • 5TIAN H Y,XIONG W,WEI J Z,et al. Gene Transfec- tion of Hyperbranched PEI Grafted by Hydrophobic Amino Acid Segment PBLG [J]. Biomaterials, 2007, 28:2899-907.
  • 6WEI Y,YANG C C. A New Synthesis of Aniline Oli- gomers with Three to Eight Amine Units[J]. Synthetic Metals, 1997,84 : 289-291.
  • 7BENDREA A D, CIANGA Luminita, CIANGA L A. Review Paper:Progress in the Field of Conducting Pol- ymers for Tissue Engineering Applications[J]. Journal of Biomaterials Applications, 2011,26 : 3-84.
  • 8HAI Binh Nquyen,VAN Chuc Nquyen,et al. Graphene Patterned Polyaniline-Based Biosensor for Glucose De- tection Advances in Natural[J-]. Sciences: Nanoscience Nanotechnology, 2012,3 :025011.
  • 9GUO B L, ANN-CHRISTINE Albertsson. Universal Two-Step Approach to Degradable and Electroactive Block Copolymers and Networks from Combined Ring- Opening Polymerization and Post-Functionalization via Oxidative Coupling Reactions [J-]. Macromolecules, 2011,44 : 5227-5236.
  • 10YAO Y,LI W W,WANG S B,et al. Polypeptide Modi- fication of Multiwalled Carbon Nanotubes by a Araft- From Approach[J-]. Macromolecular Rapid Communi- cations, 2006,27 : 2019-2025.

引证文献4

二级引证文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部