帕瑞昔布钠用于经尿道膀胱肿瘤切除手术后镇痛50例

Fifty Cases of Postoperative Analgesia by Parecoxib Soddium on Transurethral Resection of Bladder Tumor

目的探讨帕瑞昔布钠对经尿道膀胱肿瘤切除术患者手术后镇痛的临床效果。方法选择硬膜外麻醉下行择期经尿道膀胱肿瘤切除手术患者100例,随机分为治疗组和对照组各50例,手术结束前分别静脉注射帕瑞昔布钠40 mg或等容量0.9%氯化钠溶液。用视觉模拟评分法(VAS评分)分别对两组患者手术后1,3,6,12 h进行疼痛评分,并观察记录患者膀胱痉挛次数、胃肠道不良反应及患者满意程度。结果治疗组患者手术后1,3,6,12 h内的VAS评分分别为1.92±0.85,2.35±0.72,2.56±0.91,2.79±1.01,均明显低于对照组相同时间点的VAS评分(均P<0.05)。治疗组和对照组手术后12 h内膀胱痉挛分别为(3.2±1.3),(7.8±2.9)次;治疗组患者手术后满意度明显高于对照组(P<0.05);两组患者胃肠道不良反应差异无统计学意义。结论经尿道膀胱肿瘤切除术患者手术后静脉注射帕瑞昔布钠40 mg具有良好的镇痛效果,而且减少了膀胱痉挛的发生,患者满意度高。

Objective To investigate the analgesic effects of parecoxib sodium on transurethral resection of bladder tumor.Methods A total of 100 patients undergoing selective transurethral resection of bladder tumor under epidural anesthesia were randomly divided into two groups with 50 cases in each.Group P received perecoxib sodium 40 mg i.v.just before the end of operation,and group C received equal volume of normal saline.The pain scores of both groups were assessed by visual analog scale（VAS） within 1 h,3 h,6 h and 12 h post-operation.The incidence of bladder spasm,gastrointestinal side effects and degree of satisfaction in patients were also observed and recorded at the same time point.Results The VAS scores in group P within 12 post-operation were 1.92±0.85,2.35±0.72,2.56±0.91,2.79±1.01,respectively,which were significantly lower than those in the control group（P〈0.05）.The bladder spasm developed in the treatment and control groups within 12 h post-operation was 3.2±1.3,7.8±2.9,respectively.Degree of satisfaction in the former group was remarkably higher than that in the latter.There was no significant difference between both groups.Conclusion Intravenous injection of 40 mg parecoxib sodium exhibits favorable post-operative analgesia and perfect satisfaction,and reduces the bladder spasm in patients undergoing transurethral resection of bladder tumor.