血清抵抗素水平与急性脑缺血病情进展的相关性

Serum resistin levels and progression of acute cerebral ischemia associated

目的探讨急性脑缺血患者血清抵抗素的含量变化及其在脑缺血病情进展过程中的作用与意义。方法采用酶联免疫吸附法(ELISA)检测80例研究对象的血清抵抗素含量,急性脑缺血患者60例,其在稳定型脑梗死组、进展型脑梗死组、短暂性脑缺血发作组各20例,正常对照组20例。结果①进展型脑梗死组血清抵抗素水平高于稳定型脑梗死组,而稳定型脑梗死组抵抗素水平高于短暂性脑缺血发作组,差异有统计学意义(P<0.05)。②急性脑缺血患者血清抵抗素含量变化与神经功能缺损程度密切相关(r=0.657,P=0.001)。结论检测急性脑缺血患者血清抵抗素的含量变化有助于判断病情的严重程度及神经功能缺损程度,提示抵抗素水平与急性脑缺血病情进展呈正相关。

Objective To investigate the serum of patients with acute cerebral ischemia is the content of change and its resistance to ischemic disease progression in the role and significance. Methods Enzyme-linked immunosorbent assay（ELISA） detection of 80 cases studied serum resistin levels, 60 patients with acute cerebral ischemia,cerebral infarction in the stable, progressive cerebral infarction, transient ischemic attack group the 20 cases, the normal control group of 20 cases. Results ①progressive cerebral in- farction serum resistin levels than stable cerebral infarction, cerebral infarction and stable levels of resistin than transient ischemic attack group, the difference was statistically significant（P〈0.05）.②in patients with acute ischemic changes in serum resistin levels and neurological deficits are closely related（r=0.657,P=0.001）. Conclusion The detection of acute cerebral ischemia in patients with changes in serum resistin levels help determine the severity and extent of neurological impairment, suggesting that resistin levels in patients with acute cerebral ischemia was positively correlated with disease progression .