摘要
基质金属蛋白酶(MMPs)有降解脑血管基膜,促进中性粒细胞和炎性因子迁移的作用,这与脑卒中后急性期脑损伤有关。而在脑卒中恢复期,MMPs在细胞外基质的修复和神经血管重构中起重要作用。组织型纤溶酶原激活剂(t-PA)对脑损伤有一定保护作用,但在脑缺血和炎性因子作用下可以上调MMPs表达,不仅加重脑损伤,同时也是采用t-PA溶栓治疗后发生出血转化的主要机制。现就MMPs和t-PA在脑卒中后脑损伤中的作用及与此相关的药物研究予以综述。
Matrix metalloproteinases （MMPs）can degrade cerebral vascular basement membrane andpromote the migration of neutrophils and inflammatory cytokines, which are deleterious actions m acute stroke. However, MMPs may play beneficial roles during stroke recovery. MMPs may mediate neurovascular remodeling and repair the extracellular matrix. Tissue-type plasminogen activator（t-PA） has a protective effect on brain injury, but under the action of cerebral ischemia and inflammatory cytokines, it can up-regulate the expression of MMPs ,which not only aggravates the brain damage, but also is the main mechanism of hemor- rhage transformation after thrombolytic therapy by t-PA. Here is to make a review on the role of MMPs and t- PA in brain iniurv after stroke and the related drug studies.
出处
《医学综述》
2012年第17期2732-2736,共5页
Medical Recapitulate
基金
国家自然科学基金(81072801)
北京市自然科学基金(7093129)
