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锌-α_2-糖蛋白与脂代谢关系的研究进展 被引量：1

Research Progress of Correlation between Zinc-α_2-glycoprotein and Lipid Metabolism
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摘要 锌-α2-糖蛋白(ZAG)是由脂肪细胞分泌的一种新型脂肪动员因子,存在于人血浆和多种体液中。它是一种多功能糖蛋白,其分子结构中具有与脂肪动员相关的特征性疏水槽结构,能够促进脂肪的分解和利用,并通过协调多种信号转导途径和其他脂肪细胞因子,参与脂代谢的调控。因此,ZAG很可能成为脂代谢紊乱及其相关疾病治疗的潜在作用靶点。 Zinc-α2-glycoprotein（ZAG） is a novel lipid mobilizing factor secreted by adipocyte. It pres- ents in plasma and other body fluids of human, containing characteristic hydrophobic groove related with lipid mobilizing. As a multi-function glycoprotein, ZAG can enable decomposition and utilization of fat by coordina- ting many signal transduction pathways and other fat cytokines, thus influencing lipid metabolism. Studies show ZAG may be a potential therapeutic target for lipid metabolism disorders and related diseases.
作者 周跃辉 袁海平
机构地区 上海体育学院运动科学学院
出处 《医学综述》 2012年第17期2755-2758,共4页 Medical Recapitulate
基金 上海市重点学科建设项目资助(S30802)
关键词 锌-α2-糖蛋白 多功能糖蛋白 脂代谢 Zinc-α2 -glycoprotein Multi-function glycoprotein Lipid metabolism
分类号 R589.2 [医药卫生—内分泌]
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参考文献22

  • 1Bing C, Bao Y, Jenkins J, et al. Zinc-c2-glycoprotein, a lipid mo- bilising factor, is expressed in adipocytes, and is up-regulated in mice with cancer cachexia[ J]. Proc Natl Acad Sci USA,2004,101 (8) :2500-2505.
  • 2Hassan MI, Waheed A,Yadav S, et al. Zinc-ct2-glycoprotein: a mul- tidisciplinary protein[J]. Mol Cancer Res,2008,6(6) :892-906.
  • 3McDermott LC, Freel JA, West AP, et al. Zn-oL2-glycoprotein, an MHC class I-related glycoprotein regulator of adipose tissues: modification or abrogation of ligand binding by site-directed muta- genesis[J]. Biochemistry,2006,45 (7) :2035-2041.
  • 4Jain S, Rajput A, Kumar Y, et al. Proteomic analysis of urinary pro- tein markers for accurate prediction of diabetic kidney disorder [ J]. J Assoc Physicians India,2005,53 (6) :513-520.
  • 5Bing C, Trayhurn P. New insights into adipose tissue atrophy in cancer eaehexia [ J ]. Proe Nutr Soe, 2009,68 ( 4 ) : 385 -392.
  • 6Gao D, Trayhum P, Bing C. Macrophage-secreted factors inhibit ZAG expression and secretion by human adipocytes [ J ]. Mol Cell Endocrino1,2010,325 (1/2) : 135-142.
  • 7Hale LP, Price DT, Sanchez LM, et al. Zinc alpha2 glycoprotein is expressed by malignant prostatic epithelium and may serve as a po- tential serum marker for prostate cancer [ J]. Clin Cancer Res, 2001.7(4) 846-853.
  • 8李薇薇,袁海平,刘琼.能量限制与有氧运动对小鼠脂肪组织ZAGmRNA表达的影响[J].上海体育学院学报,2011,35(5):37-41. 被引量：2
  • 9Rolli V, Radosavljevic M, Astier V, et al. Lipolysis is altered in MHC class I zinc-alpha ( 2 ) -glycoprotein deficient mice [ J ]. FEBS Lett,2007,581 (3) :394-400.
  • 10Gong FY, Zhang S J, Deng JY, et al. Zinc-alpha2-glycoprotein is in- volved in regulation of body weight through inhibition of lipogenic enzymes in adipose tissue [ J ]. Intl J Obes (Lond) , 2009,33 ( 9 ) : 1023-1030.

二级参考文献20

  • 1李洁,王玉侠.肥胖发生机制及减肥方法的研究现状[J].中国体育科技,2006,42(2):64-67. 被引量：34
  • 2WHO. Technical Report Series 894 Obesity: Preventing and Managing the Global Epidemic E R ]. Geneva, Switzerland, 2000.
  • 3Bing C, Mracek T, Gao D, et al. Zinc-a2-Glycoprotein: An Adipokine Modulator of Body Fat Mass [ J 1. International Journal of Obesity ,2010 ( 12 ) : 1 - 7.
  • 4Fernando P, Onen A, Offman Goetz. Predicting Submaximal Axygen Consumption during Treadmill Running in Mice [ J]. Can J Physiol Pharmacol, 1993,71 : 854 - 857.
  • 5Ahima RS, Flier JS. Adipose Tissue as an Endocrineorgan [ J]. Trends Endocrinol. Metab,2000,11:327 - 332.
  • 6Chen Bing, Yi Bao, John Jenkins, et al. Zinc-α2- Glycoprotein, a Lipid Mobilizing Factor, is Expressed in Adipocytes and is Up-Regulated in Mice with Cancer Cachexia[ J]. PNAS ,2004,101:2 500 - 2 505.
  • 7Bing C, Trayhurn P. New Insights Into Adipose Tissue Atrophy in Cancer Cachexia [ J ]. Proc Nutr Soc, 2009,68 (4) :385 - 392.
  • 8Yi Bao, Chen Bing, Leif Hunter. Zinc-a2-Glycoprotein, a Lipid Mobilizing Factor, is Expressed and Secreted by Human ( SGBS ) Adipocytes [ J ]. FEBS Letters, 2005,579 :41 - 47.
  • 9Russell ST, Zimmerman TP, Domin BA, et al. Induction of Lipolysis in Vitro and Loss of Body Fat in Vivo by Zinc-AIpha2-Glycoprotein[ J ]. Biochim Biophys Acta, 2004.1 636( 1 ) :59 -68.
  • 10David M. Selva, Albert Lecube, Cristina Hernandez, et al. Lower Zinc-Alpha2-Glycoprotein Production by Adipose Tissue and Liver in Obese Patients Unrelated to Insulin Resistance[ J], J Clin Endocrinol Metab ,November,2009, 94( 11 ) :4 499 -4 507.

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医学综述
2012年 第17期

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