硫化氢对呼吸中枢节律性的调节作用

Function of Hydrogen Sulfide on Respiratory Central Rhythm

硫化氢(H2S)已成为第三种内源性气体信号分子。H2S由胱硫醚-β-合酶、胱硫醚-γ-裂解酶和3-巯基丙酮酸转硫酶三种酶产生。呼吸节律产生于中枢神经系统脑干延髓的一个局限区域——前包钦格复合体,生理浓度的H2S对中枢性呼吸节律有"先抑制后兴奋"的双向调节作用,而高浓度H2S对呼吸节律产生抑制作用。H2S可能是通过KATP通道和环磷酸腺苷途径参与呼吸中枢节律性调控。

Hydrogen sulfide （H2 S） has emerged as the third endogenous gaseous mediator. H2 S is gener- ated by three enzymes：cystathionine-β-synthase（CBS） ,cystathionine-γ-1yase（CSE） and 3-mercaptopyruvate sulfurtransferase（3MST）. Respiratory rhythms are generated from a limited area-pre-Bontzinger complex （ Pre-BotC）, of medulla ohlongata. H2 S of physical concentration regulates bilaterally respiratory center rhythms through ＂first depression and then excitation＂. H2 S of high concentration, however, depresses re- spiratory rhythms. H2 S possibley regulates respiratory center rhythms through KATP channel and cyclic adeno- sine monophosphate（cAMP） pathway.