抗肿瘤药物信号转导通路的研究进展

Research Progress of the Signal Transduction Pathways of Antitumor Drugs

细胞信号转导通路在肿瘤的发生、发展中发挥着重要作用。近年来,人们逐渐认识到肿瘤发生的本质是细胞信号转导通路异常所致。一系列针对肿瘤细胞内信号转导通路中关键分子的靶向性抗肿瘤药物的研发成为现阶段抗肿瘤药物研发的焦点,这可能在癌症治疗领域取得突破性和革命性进展。现着重介绍几类在细胞信号转导通路方面研究较成熟的抗肿瘤药物。

Cell signal transduction pathway plays a vital role in tumor development. In recent years, peo- ple gradually realize that the nature of tumor is caused by the abnormal cell signal transduction pathway. So, a series of studies on antitumor drugs targeted at the key elements are becoming the focus ,which may be the breakthrough and revolutionary progress in the field of cancer treatment. Here is to introduce several kinds of antitumor drugs,the pathways of which are relatively well studied.