摘要
目的探讨血清胱抑素C(Cys C)检测对早期诊断肝炎后肝硬化患者肾功能损害的意义。方法 38例肝炎后肝硬化患者按照Child-Pugh分级分为三组(A级10例、B级14例、C级14例),另选20例健康者为对照组,测定四组患者的血尿素氮(BUN)、24 h肌酐清除率(Ccr)、血清肌酐(SCr)和血清Cys C水平,并进行比较。结果随着Child-Pugh分级的上升,Ccr逐渐下降,SCr和Cys C逐渐上升(P<0.05);Cys C、SCr均与Ccr有着显著的负相关性(P<0.01),而Cys C的相关系数较高。结论 Cys C能更早期发现肝炎后肝硬化患者肾功能损害,常规监测肝炎后肝硬化患者的Cys C水平,对防治肝肾综合征的发生具有积极意义。
Objective To investigate the diagnostic value of cystatin C （ Cys C） for early detection of re- nal injury in patients with posthepatitis cirrhosis. Methods 38 cases of liver cirrhosis patients according to Child-Pugh classification were divided into three groups（ class A 10 cases, class B 14 cases, class C 14 ca- ses） ;another 20 healthy people were selected as control group, blood urea nitrogen （BUN）, 24 h creatinine clearance rate（ Ccr）, serum creatinine（SCr） and serum Cys C levels of the four groups were tested. Results With the rise in Child-Pugh classification, Ccr decreased and SCr and Cys C increased gradually（ P 〈 0.05 ） ; Cys C and SCr were both significantly inverse correlated with Ccr（ P 〈 0. 01 ）, while the Cys C correlation co- efficient was higher. Conclusion Cystatin C is a more sensitive marker of renal injury in posthepatitis cir- rhosis. Routine monitoring of Cys C level in patients with posthepatitis cirrhosis could contribute to the pre- vention and treatment of hepatorenal syndrome.
出处
《医学综述》
2012年第17期2878-2880,共3页
Medical Recapitulate
