6Akira S,Uematsu S,Takeuchi O.Pathogen recognition and innateimmunity[J].Cell,2006,124(4):783-801.
7Morise K,Furusawa A,Yamamoto H,et al.Role of gut hormones inirritable bowel syndrome[J].Nihon Rinsho,1992,50(11):2 697-2 702.
8Toumi F,Neunlist M,Denis M G,et al.Vasoactive intestinal peptideinduces IL-8 production in human colonic epithelial cells via MAPkinase-dependent and PKA-independent pathway[s J].Biochem Bio-phys Res Commun,2004,317(2):187-191.
9Belai A,Boulos P B,Robson T,et al.Neurochemical coding in thesmall intestine of patients with Crohn′s disease[J].Gut,1997,40(6):767-774.
6[1]LOFTUS E V,SCHOENFELD P,SANDBORN W J.The epidemiology and natural history of Crohn's disease in population-based patient cohorts from North America: a systematic review [J].Aliment Pharmacol Ther,2002,16(1):51-60.
7[2]LOFTUS E V,SILVERSTEIN M D,SANDBORN W J,et al.Crohn's disease in Olmsted County,Minnesota,1940-1993: incidence,prevalence,and survival[J].Gastroenterology,1998,114(6):1161-1168.
8[3]ARMITAGE E,DRUMMOND H E,WILSON D C,et al.Increasing incidence of both juvenile-onset Crohn's disease and ulcerative colitis in Scotland[J].Eur J Gastroenterol Hepatol,2001,13(12):1439-1447.
9[5]TRIANTAFILLIDIS J K,EMMANOUILIDIS A,MANOUSOS O,et al.Clinical patterns of Crohn's disease in Greece: a follow-up study of 155 cases[J].Digestion,2000,61(2):121-128
10[6]FREEMAN H J.Familial Crohn's disease in single or multiple first-degree relatives[J].J Clin Gastroenterol,2002,35(1):9-13.
