复方红花微乳处方药物配比的筛选研究

Screening on Medicine Ratio of Safflower Microemulsion Prescription

目的:将红花和利多卡因按不同比例制备成6种微乳剂,对其镇痛、活血化瘀作用药效进行实验研究,以筛选最优处方。方法:观察6个处方对醋酸致小鼠扭体反应以及对小鼠出凝血时间的影响。结果:处方6的镇痛作用较其他处方显著,差异有统计学意义(P<0.01)。结论:复方红花微乳处方最佳配比的探索研究,对于进一步将之开发为一种应用于临床的活血化瘀经皮给药制剂具有重要的意义。

Objective： Six kinds of microemulsion were prepared according to different proportion of safflower and lidocaine.Then optimum prescription was screened out according to analgesic effect and stasis-eliminating effect of prescription.Methods：Effects of 6 kinds of mieroemulsion on acetic acid-induced writhing response of mice as well as bleeding time and clotting time of mice were observed. Results：Analgesic effect of the sixth prescription was better than that of other prescriptions（P〈0.01 ）. Conclusion：Exploration on optimal matching of safflower-lidocaine was conducted in this experiment, and it provides value to develop transdermal drug delivery preparations of promoting blood circulation and removing blood stasis.