荧光增白剂ER-I的中试研究

Study of scale up of fluorescent whitening agent ER-I

以亚磷酸三乙酯、邻氰基氯苄和对苯二甲醛为原料,经Abuzov酯化反应和Witting反应合成荧光增白剂ER-I,详细研究原料比、反应温度、加料方法对反应的影响。结果表明,最佳的中试工艺为:磷酸酯和氯苄的比为1.1∶1.0,加料温度控制在140℃,反应时间为9 h,两步反应总收率93%。6次中试数据验证了该工艺参数稳定可靠。

：The fluorescent brightener ER-I was synthesized through Abuzov esterification and Witting con- densation with the raw material triethyl phosphite ,2-（chloromethyl） benzonitrile and 1,4-phthalaldehyde. The influence factors such as reaction temperature, feeding method and the ratio of raw material were reasearched in detail. Results showed that the optimum reaction condition was as follows：when the ratio of triethyl phosphite ： benzyl chloride 1.1：1.0 was used, temperature of feed was 140 ℃ ,the reaction time was 9 h, the total yield 93%. The stabilization of technological condition was confirmed by 6 time tests.