结直肠癌肝转移临床治疗现状

Clinical therapy of the colorectal liver metastases

目前,结直肠癌发病率呈上升趋势,肝脏是结直肠癌最易发生转移的靶器官之一,手术是惟一有效的治愈手段。结直肠癌肝转移(CLM)的治疗正在由"手术切除-术后化疗"向"新辅助治疗-手术切除-靶器官局部治疗-术后化疗"等多学科综合治疗(MST)模式转变。该模式的核心问题是如何创造条件进行根治性手术切除及预防术后复发。切缘阴性的病理性根治(R0)切除联合提高肿瘤局控率的肝脏靶器官局部治疗,是控制肿瘤复发的重要方法。

At present,the incidence of colorectal cancer is rising,and liver is one of the most target organs prone to transfer.Surgery is the only effective means of cure.The treatment of colorectal liver metastases（CLM） is shifted from surgical resection - postoperative chemotherapy to multidisciplinary sequential treatment（MST）,such as neoadjuvant therapy-surgical excision-the topical treatment of target organ-postoperative chemotherapy.The core issue in the mode is how to create the conditions for radical surgical resection and prevention of postoperative recurrence.It is an important method to control tumor recurrence by negative margins of pathological radical（RO） resection combined with local treatment of liver target organ of improving local control rate of tumor.