结直肠癌中OPN和ADAM17的表达及其意义

目的探讨OPN、ADAM17在结直肠癌、正常肠黏膜组织中的表达情况及其临床意义。方法应用SP免疫组化方法检测60例结直肠癌（30例结直肠癌肝转移）、12例正常结直肠黏膜组织（对照组）中OPN、ADAM17的表达，分析其表达水平的差异性。结果（1）结直肠癌组织中OPN、ADAM17阳性表达率分别为71．6％、75％，与正常组比较，差异有统计学意义（P〈0．05）。（2）OPN、ADAM17在肝转移组、DukesC＋D期组中的阳性表达率均高于相应对照组，且差异有统计学意义（P〈0．05）。（3）OPN、ADAM17在结直肠癌的表达与患者的年龄、性别、部位及肿瘤大小无明显相关性（P〉0．05）。（4）OPN、ADAM17的表达呈正相关。结论OPN、ADAM17的表达与结直肠癌侵袭转移的发生有密切关系，在结直肠癌的发生、发展过程中可能具有协同作用，对判断结直肠癌预后具有重要意义。

Objective To eploere the expressions of OPN, ADAM17 in colorectal cancer and normal colorectal mucous membrane and their clinical significance. Methods The SP immunohistochemisty was applied to detect the expression of OPN, ADAM17 in 60 cases of colorectal cancer（30 cases of liver metastasis from colorectal cancer）, 12 normal colorectal mucous membrane（control）, and the difference in the expression was analysed. Results （I） The expressions of OPN, ADAM17 in colorectal cancer tissue was 71.6%, 75%, which was significantly different from the normal group. （ 2 ） The expressions of OPN, ADAM17 were significantly higher in the liver metastasis group and Dukes C＋D group than those in the control group （ P〈0.05 ） . （ 3 ） There was no significantly correlation between the expression of OPN, ADAM17 in colorectal cancer and the patients＇ age, gender, tumor location and size （P〉0.05 ） . （ 4 ） The expressions of OPN, ADAM17 were positively correlated. Conclusions The expressions of OPN, ADAM17 were closely related to the metastasis of colorectal cancer, which may have a synergetic effect in the carcinogenesis and progress of colorectal cancer and is important for the prognosis.