复方苦参注射液、IL-2及α-干扰素治疗肺癌伴恶性胸腔积液疗效

Observing therapeutic efficiency of fufangkushen injection,IL-2,α-IFN on lung cancer accompanied with malignancy pleural effusions

目的观察复方苦参注射液、IL-2及干扰素辅助治疗肺癌伴恶性胸腔积液疗效和不良反应。方法 150例肺癌伴胸腔积液患者随机分治疗组和对照组。治疗组分为a、b、c三组,分别在胸腔内注入复方苦参注射液+IL-2、复方苦参注射液+α-干扰素、IL-2+α-干扰素。对照组分为d、e、f组,分别在胸腔内注入复方苦参注射液、IL-2、α-干扰素。4周后观察两组疗效及不良反应。结果复方苦参注射液、IL-2及α-干扰素两两联合治疗肺癌伴胸腔积液的有效率明显优于单用一种药物治疗;复方苦参注射液联合α-干扰素的有效率最高.不良反应中,治疗组中发热、胸痛及胃肠道反应等毒副反应的发生率均明显少于对照组。结论复方苦参注射液、IL-2及α-干扰素两两联合辅助治疗肺癌胸腔积液效果肯定,其中以复方苦参注射液联合IL-2或α-干扰素效果最佳。

Objective To Observe therapeutic efficiency and adverse reaction of fufangkushen injection, IL-2, α-IFN on lung cancer with pleural effusions. Methods One hundred and fifty patients with lung cancer accompanied with pleural effusions were radomly divided into treatment group and matched group. The treatment group were divided into a, b, c three groups and injcted fufangkushen plus IL-2, fufangkushen plus α-tFN, IL-2 plus α-IFN respecttively. The matched group were divided into d,e, f three groups and injcted fufangkushen , IL-2 and α-IFN respecttively. Observe therapeutic efficiency and adverse reaction after four weeks. Results The effective rate of fufangkushen ,IL-2 and α-IFN two by two was obviouly superior to single pharmacotherapy. The effective rate of fufangkushen plus ct-IFN was highest. In adverse reactions ,the incidence sof fever,chest pains and the reaction of gastrointestinal tract in treatment group were obviouly less than matched group. Conclusion The effect of fufangkushen , IL-2 and α-IFN two by two on lung cancer with pleural effusions was definite,moreover, the effect of fufangknshen plus IL-2 or α-IFN was the best.