肺癌患者介入治疗前后血液学肿瘤标志物与CT影像学检测的变化

Changes of hematologic tumor marker and CT imaging of lung cancer patients before and after interventional therapy

目的探讨肺癌患者介入治疗前后血液学相关肿瘤标志物与CT影像学检测的变化。方法原发性肺癌患者40例,均采用介入治疗,介入前后进行肿瘤标志物与CT影像学相关指标检测并进行疗效评价。结果经过治疗后,40例患者有效率为32.5%。不同疗效分组治疗前肿瘤标志物水平无显著差异(P>0.05)。治疗后PR组SCC、CEA、NSE及VEGF明显减低(P<0.05),而NC+PD组CEA及VEGF明显升高(P<0.05)。CT影像学检测显示肺动脉AT下降、AC增加明显,EDV流速明显减低,治疗前后有显著性差异(P<0.05)。结论介入治疗具有比较好的临床效果,可以明显改变血液学肿瘤标志物相关指标与CT影像学指标。

Objective To investigate the changes of hematologic tumor marker and CT imaging of lung cancer patients before and after interventional therapy. Methods 40 cases of primary lung cancer were given interventional treatment. Hematologic tumor marker and CT imaging of lung cancer patients before and after interventional therapy were performed. Results After treatment, the effective rate of 40 patients was 32.5 %. There were no significant differences in the level of tumor markers among different groups before treatment （P 〉 0. 05）. After treatment, the SCC, CEA, NSE and VEGF in the PR group were more significantly reduced, while the CEA and VEGF of the NC ＋ PD group were more significantly increased （ P 〈 0.05 ）. CT imaging showed that the pulmonary artery AT decreased more sig- nificantly, AC increased more significantly, and the EDV flow rate decreased more significantly （ P 〈 0. 05 ）. Conclusion Interventional treatment had a good clinical effect, which can significantly improve the indices of hematologic tumor marker and CT imaging of lung cancer.