158例新生儿败血症病原菌种类及其耐药性

Species and drug-resistance of pathogens in 158 cases of neonatal septicemia

目的了解引起新生儿败血症的病原菌种类及其耐药情况,为临床治疗提供依据。方法对某院2007年1月—2010年12月收治的158例新生儿败血症患儿血培养阳性菌及其药敏试验结果进行分析。结果 158例新生儿败血症患儿血培养居前3位的细菌分别为凝固酶阴性葡萄球菌(77株,48.73%)、金黄色葡萄球菌(44株,27.84%)、大肠埃希菌(19株,12.03%)。金黄色葡萄球菌和凝固酶阴性葡萄球菌对青霉素、红霉素的耐药率较高,对万古霉素、替考拉宁无耐药株;大肠埃希菌对环丙沙星、头孢噻肟、复方磺胺甲口恶唑的耐药率较高,对四环素、头孢哌酮∕舒巴坦的耐药率较低,对亚胺培南、美罗培南无耐药株。结论葡萄球菌属与大肠埃希菌是引起新生儿败血症的主要病原体,应重视其耐药性检测,合理选择抗菌药物进行目标性治疗。

Objective To investigate species and drug-resistance of pathogens in neonatal septicemia,and provide the basis for clinical treatment.Methods Analysis was made on positive blood culture and antimicrobial susceptibility testing results of pathogens from 158 neonates with septicemia who were admitted in a hospital from January 2007 to December 2010.Results The top 3 bacteria in blood culture were coagulase-negative Staphylococcus（CoNS,77 isolates,48.73%）,Staphylococcus aureus（S.aureus,44 isolates,27.84%） and Escherichia coli（E.coli,19 isolates,12.03%）;S.aureus and CoNS had high resistant rates to penicillin and erythromycin,but had no resistance to vancomycin and teicoplanin;E.coli had high resistance to ciprofloxacin,cefotaxime,trimethoprim/sulfamethoxazole,but had low resistance to tetracycline,cefoperazone/sulbactam,all were sensitive to imipenem and meropenem.Conclusion Staphylococcus spp.and E.coli are the major pathogens in neonatal septicemia,detection of antimicrobial resistance and choice of rational antimicrobial agents for treatment should be stressed.