2型糖尿病患者空腹血糖、糖化血红蛋白、纤维蛋白原、血常规之间的相关性研究

Study on correlation of fasting blood glucose,saccharified hemoglobin,fibrinogen,and routine blood test in type 2 diabetes

目的探讨2型糖尿病患者血糖、糖化血红蛋白、纤维蛋白原、血常规之间的相关性。方法研究对象分为糖尿病组和非糖尿病组、糖化血红蛋白升高组与糖化血红蛋白正常组,分析研究对象的空腹血糖、糖化血红蛋白、纤维蛋白原、血常规的资料和年龄、体重指数、腹围、收缩压、舒张压、性别、族别、吸烟史、心电图改变及相关性。结果 2型糖尿病组与非糖尿病组、糖化血红蛋白升高组与正常组资料比较,族别、性别、年龄、腹围、血压、单核细胞百分比和血小板平均分布宽度有显著性差异;2型糖尿病患者空腹血糖与糖化血红蛋白、中性粒细胞百分比相关。结论不同的性别、种族、年龄、肥胖、血压、吸烟、饮酒,是2型糖尿病发病危险因素;糖化血红蛋白与白细胞计数及淋巴细胞计数的相关性提示:2型糖尿病存在免疫功能的异常,常规血液学检查项目对于2型糖尿病早期诊断、疗效及预后判断有一定的临床意义;定期监测糖尿病患者血小板参数的变化,有利于提高对糖尿病肾损伤早期病变的认识并尽早采取有效措施,对于预防肾脏严重并发症至关重要;在临床上控制空腹血糖以观察疗效时,应充分考虑纤维蛋白原、糖化血红蛋白、外周血细胞计数与2型糖尿病的相关性。

Objective To investigate correlation among fasting blood glucose, saccharified hemoglobin, fibrinogen, and the routine blood test results in type 2 diabetic patients. Methods Subjects were divided into diabetic and non-diabetic group, elevated saccharified hemoglobin group and saccharified hemoglobin normal group. Fasting blood glucose, sacchari- fied hemoglobin, fibrinogen, routine blood test and age, body mass index, waist circumference, systolic blood pressure, dia- stolic blood pressure, gender, nationality, smoking history, and ECG changes were recorded, and their correlation were ana- lyzed. Results Compared with the non-diabetes group, variables such as nationality, gender, age, BMI, waist circumfe- rence, blood pressure, mononuclear cells percentage, hemoglobin, and platelet average distribution width were significantly different in the type 2 diabetes group; Compared with the saccharified hemoglobin normal group, nationality, gender, age, waist circumference, blood pressure, WBC count number, mononuclear cells percentage, lymph cell count number, and plate- let average distribution width were significantly different in the elevated saccharified hemoglobin group. Fasting blood glu- cose in type 2 diabetic patients significantly related to saecharified hemoglobin and neutrophils percentage. Conclusions Different gender, nationality, age, obesity, blood pressure, smoking, and alcohol consumption are risk factors for type 2 diabe- tes. The correlation among saccharified hemoglobin, white blood cell count, and lymphocyte count can suggest abnormal im-mune function of the type 2 diabetes patients; Routine hematological examination have certain clinical significance Ior early diagnosis, curative effect and prognosis for type 2 diabetes. Regular monitoring of changes in platelet parameters in patients with type 2 diabetes helps to improve the awareness of early lesions of diabetic renal injury, and helps to take effective mea- sures as soon as possible, this step is essential for the prevention of serious renal complications of type 2 diabetes. In control- ling fasting blood glucose in clinical practice, clinicians should seriously consider the correlation among fibrinogen, sacchari- fled hemoglobin, and peripheral blood cell counts in type 2 diabetes patients.