老年腔隙性脑梗死患者血清Hcy、HDL-C和ApoA1水平及其相互关系

The levels of serum Hcy,HDL-C and ApoA1 in elderly patients with lacunar infarction and their correlation

目的观察老年腔隙性脑梗死患者血清同型半胱氨酸(Hcy)、载脂蛋白A1(ApoA1)、高密度脂蛋白胆固醇(HDL-C)水平及三者之间的关系。方法选择老年腔隙性脑梗死住院患者60例为观察组,同期健康老年人55例为对照组。入选对象在入院后进行Hcy、ApoA1、HDL-C水平的测定,并进行统计分析。结果观察组血清Hcy水平较对照组明显升高,而HDL-C和ApoA1较对照组明显降低,且Hcy和HDL-C之间呈负相关关系(r=-0.306,P<0.01)。结论 Hcy在动脉粥样硬化的形成中具有重要作用,其与HDL-C的负相关关系可能是其参与动脉粥样硬化的形成机制之一。

Objective It is to observe the levels of Hcy, HDL - C ApoA1 in elderly patients with lacunar infarction and their correlation. Methods 60 cases of elderly patients with lacunar infarction were chosen as observation group, 55 cases of heathy elderly people in the same stage were chosen as control group. The levels of serum Hcy, HDL - C and ApoA1 in all the chosen subjects were determined after admission to hospital, and the results were analyzed by statistical analysis. Results The level of serum Hcy in observation group was obviously higher than that in control group, and the levels of HDL - C and ApoA1 were obviously lower than that in control group, and there was a negative relationship between Hcy and HDL - C （ r = - 0. 306, P 〈 0.01 ）. Conclusion Hey plays an important role in the development of atherosclerosis, and its negative correlation with HDL - C may be one of the mechanisms of the role it plays.