大剂量维生素C在胰腺炎治疗中的辅助作用

Large Doses of Vitamin C in the Treatment of Pancreatitis by Auxiliary Function

目的:了解大剂量维生素C对胰腺炎的辅助治疗作用。方法:随机选择21例急性胰腺炎患者和8例重症患者,采用在常规治疗基础上静脉滴注维生素C的治疗方法,观察患者白细胞、血淀粉酶、尿淀粉酶、CRP和重症患者APPECPⅡ评分、MODS评分、氧合指数、总胆红素、谷草转氨酶、尿素氮的变化。结果:治疗5d后,急性胰腺炎患者白细胞、血淀粉酶、尿淀粉酶、C反应蛋白数值下降;重症急性胰腺炎患者MODS评分(P<0.01)和APACHEⅡ评分(P<0.05)均得到改善,氧合指数极显著增加,谷草转氨酶显著降低,总胆红素、尿素氮含量变化不明显。结论:大剂量维生素C能清除异常增多的氧自由基,减轻胰腺炎患者的炎症反应,改善脏器功能。

Objective ：To understand the large doses of vitamin C on pancreatitis treated with adjuvant effect.Methods ：21 patients with acute pancreatitis patients and 8 cases of patients with severe, adopted on the basis of routine treatment of intravenous vitamin C treatment, observed in patients with white blood cell, blood amylase, urine amylase, CRP and in patients with severe APPECP Ⅱscore, MODS score, oxygenation index, total bilirubin, aspartate aminotransferase, urea nitrogen change.Results ：5 d after treatment, patients with AP white blood ceil, blood amylase, urine amylase, C reactive protein decreased numerically ; with SAP MODS score （P〈0.01） and APACHE Ⅱ （P〈0.05）were improved, oxygenation index increased significantly, aspartate aminotransferase significantly reduced, total bitirubin, urea nitrogen content did not change significantly.Conclusion ： Large doses of vitamin C can eliminate the abnormal increase of oxygen free radicals, reduce the inflammatory reaction in patients with pancreatitis, improve organ function.