Pokemon和P14^(ARF)蛋白在肝细胞癌组织中的表达及临床意义

Expression of Pokemon and P14^(ARF) Protein in Hepatocellular Carcinoma and Their Clinical Significance

目的探讨Pokemon和P14ARF蛋白在人肝细胞癌组织中的表达及相关性,分析其与肝细胞癌转移复发的关系。方法应用免疫组织化学法检测60例肝细胞癌组织和癌旁组织中Pokemon和P14ARF蛋白的表达情况。结果Pokemon及P14ARF在60例肝细胞癌及癌旁组织中的表达差异均有统计学意义(P<0.05)。Pokemon的表达与临床分期、肿瘤直径、肿瘤分化程度密切相关(P<0.05);P14ARF的表达与肿瘤分化程度密切相关(P<0.05)。Pokemon的表达和P14ARF的表达呈显著负相关(γ=-0.268,P=0.038)。结论 Pokemon和P14ARF蛋白在肝细胞癌的发生及发展中起着重要作用。

Objective To investigate the expression of Pokemon and P14ARF protein in hepatocellular carcinoma（HCC） and their correlations with metastasis and recurrence.Methods Immunohistochemisty was employed to detect the expression of Pokemon and P14ARF in 60 HCC tissues and paired adjacent liver tissues.Results The positive rates of Pokemon and P14ARF proteins in tumor tissues were significantly different compared with that in paired adjacent liver tissues.The protein expression of Pokemon was significantly correlated with clinical stage,diameter of tumor and differentiation of tumor.The protein expression of P14ARF was significantly correlated with the differentiation of tumor.There was a significant negative relationship between Pokemon and P14ARF.Conclusion Pokemon and P14ARF might contribute to the occurrence and progress of the HCC.