VEGF和Cyclin D1在子宫内膜癌中的表达及其意义

The expression and significance of VEGF and Cyclin D1 in endometrial carcinoma

目的检测血管内皮生长因子（VEGF）、细胞周期素1（Cyclin D1）在子宫内膜癌（EC）中的表达，探讨其在子宫内膜癌进展中的作用及其与临床病理特征间的关系。方法应用免疫组化方法检测VEGF和Cyclin D1在34例子宫内膜癌、20例子宫内膜上皮内瘤变（EIN）、20例正常子宫内膜组织中的表达。结果VEGF、Cyclin D1的表达在EC、EIN及正常子宫内膜组织间差异有统计学意义（P〈0．05）；VEGF的阳性表达与年龄、组织学分级、临床分期无关（P〉0．05）；Cyclin D1的表达与组织学分级有关（P〈0．05）。EC及EIN组织中的VEGF和Cyclin D1两者表达呈正相关（P〈0．05）。结论VEGF、Cyclin D1在EC及EIN组织中的异常表达提示其与肿瘤的发生、发展密切相关。

Objective To investigate the expression of VEGF and Cyclin D1 in endometrial carcinoma, to analyze the significance of vascular endothelial growth factor （VEGF） and Cyclin D1 in endometrial carcinoma development and its correlations with some clinical parameters. Methods SP immunohistoebemistry was used to detect the expression of VEGF, Cyclin D1 and compare among specimens of endometrial carcinoma （n = 34） and endometrial intraepithelial neoplasia （ n = 20） and normal endothelium tissue （ n = 20）. Results The positive rates of VEGF and Cyclin D1 in endothelial carcinoma and endothelial intraepithelial neoplasia was higher than that in normal endothelium tissue （P 〈 0. 05 ）. Cyclin D1 was positively related to differenct stages of EC. There was significant correlation between VEGF and Cyclin D1 in endothelial carcinoma and endometrial intraepithelial neoplasia （ P 〈 0.05 ）. Conclusion Abnormal expressions of VEGF and Cyelin D1 in endothelium intraepithelial neoplasia and endothelial carcinoma indicate the occurring and development of tumor.