山东省2005-2011年血友病患者HCV HIV和梅毒感染情况

An investigation of HCV HIV and syphilis infection in hemophilia patients in Shandong,2005-2011

目的了解山东省血友病患者丙型肝炎病毒(Hepatitis C virus,HCV)、人类免疫缺陷病毒(Human immunodeficiency virus,HIV)和梅毒螺旋体(Treponema pallidum,TP)的感染情况。方法对2005-2011年山东省血友病诊疗中心确诊或治疗的628例血友病患者,采用酶联免疫吸附试验检测HCV、HIV和梅毒抗体,并根据年龄段进行分组,随机选择2 474例无偿献血者为正常对照。结果 628例血友病患者抗-HCV、抗-HIV和抗-TP的阳性率分别为9.6%(60/628)、0.6%(4/628)和0.2%(1/628),总感染率为10.4%(65/628)。0～19岁、20～39岁、40～77岁年龄段患者抗-HCV阳性率分别为3.3%、9.8%和20.5%。2 474例无偿献血者抗-HCV、抗-HIV和抗-TP的阳性率分别为0.4%(11/2 474)、0和0.2%(4/2 474),总感染率为0.6%(15/2 474)。结论血友病患者抗-HCV和抗-HIV阳性率明显高于无偿献血者,HCV感染与年龄密切相关。

Objective To better understand the infection status of HCV, HIV and syphilis in hemophilia patients. Methods Serum HCV, HIV and Treponerna pallidurn, （TP） antibodies were measured by ELISA in 628 hemophilia patients and 2 474 voluntaryblood donors. Results The positive rates of HCV, HIV and TP antibodies in 628 hemophilia patients were 9.6%, 0.6% and 0.2%, respectively, and the overall infection rate was 10.4% （65/628）. The positive rates of HCV antibody in different age groups （0--19 years, 20--39 years and 40--77 years） were 3.3%, 9.8% and 20.5%, respectively. The positive rates of HCV, HIV and TP antibodies in 2 474 voluntary blood donors were 0.4%, 0.0% and 0. 2%, respectively, and the overall infection rate was 0. 6% （15/2 474）. Conclusion The positive rates of HCV and HIV antibodies in hemophilia patients were much higher than those in voluntary blood donors,the rate of HCV infection in hemophilia patients was closely correlated with age.