非洛地平缓释片对轻中度原发性高血压患者的降压疗效和对脉搏波速度的影响

The Effect and the Influence with Pulse Wave Velocity of Felodipine Sustained-release Coated Tablet in Mild to Moderate Primary Hypertension Therapy

目的:探讨非洛地平缓释片对轻中度原发性高血压患者的降压疗效和对脉搏波速度的影响。方法:根据纳入标准选取我院260例原发性高血压患者,按计划方案给予非洛地平缓释片口服治疗。观察患者入院后、治疗2周末、14周末降压疗效及脉搏波传导速度的改变情况,并进行对比分析。结果:本组研究中接受治疗研究者共260例,其所有受检者在治疗2、6、10、14周后血压水平均有不同程度改善,与基线比较差异明显,有统计学意义(P<0.01)。脉搏波变化分析所有受试者脉搏波速度变化分析,基线脉搏波速度为(10.9±2.4)m/s,经过治疗后2周、14周基线脉搏波速度为(10.3±2.1)m/s,差异明显具有统计学意义(P<0.01);心率变化分析表明非洛地平缓释片在降压同时对心率影响不大,安全性评价表示,接受治疗期间曾有68例发生不良事件,占总数26.2%。笔者认为与药物无关,且均为轻度,经过适当处理后均缓解,对本研究无影响。结论:非洛地平缓释片降压效果良好,可同时降低颈动脉-股动脉脉搏波传导速度,改善大动脉僵硬度。

Objective： To investigate the effect and the influence with pulse wave velocity of felodipine sustained-release coated tablet in mild to moderate primary hypertension therapy. Methods： 260 cases of primary hypertension patients were chosen, and treated with felodipine sustained-release coated tablet according to the plan. Recording and analyzing the effect, the change of pulse wave velocity after 2 and 14weeks. Results： After 2, 6, 10 and 14 weeks treated, the blood pressure of all patients was different change. And compared with the baseline, it had significant difference （P 〈 0.01）. Before the treatment, pulse wave velocity was （10.9 2.4） m/s, and 2 or 14 weeks later, it＇s （10.3 2.1） m/s, and there was significant difference between them （P〈 0.01）. The felodipine sustained-release coated tablet has significantly effect on decreasing blood pressure, but no effect with pulse wave velocity. There were some lightly side effects with 68 patients. Conclusion： It＇s good for mild to moderate primary hypertension to decrease blood pressure and pulse wave velocity, and make the arterial stiffness better.