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MCP-1基因及CCR2基因多态性与河南地区多发性硬化的相关性研究

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摘要 目的研究MCP-1基因-2518位点及CCR2基因-190位点多态性与河南地区多发性硬化(MS)的相关性。方法以来自河南地区的MS患者(MS组)和健康志愿者(对照组)为研究对象,利用PCR技术检测MCP-1基因及CCR2基因扩增产物酶切多态性。结果 MS组和对照组MCP-1基因-2518位点A/A、A/G、G/G三种基因型分布频率无统计学差异(P>0.05)。与对照组相比,MS组有较高的G等位基因频率,但两组差异未达统计学意义(P>0.05)。MS组和对照组CCR2基因-190位点G/G、A/G、A/A三种基因型分布频率无统计学差异(P>0.05),与对照组相比,MS组有较低的A等位基因频率,但两组差异未达统计学意义(P>0.05)。结论未发现MCP-1基因-2518位点及CCR2基因-190位点多态性与河南地区MS相关。
作者 王莉梅 张东铭
机构地区 郑州大学第一附属医院 郑州大学第二附属医院
出处 《山东医药》 CAS 2012年第33期76-78,共3页 Shandong Medical Journal
关键词 多发性硬化 多态性 单核苷酸 单核细胞化疗吸引蛋白质 CCR2
分类号 R744.51 [医药卫生—神经病学与精神病学]
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参考文献10

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山东医药
2012年 第33期

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