联合检测血清肿瘤相关抗原在乳腺癌诊断中的应用

The application of combined detection serum tumor associated antigen in the diagnosis of breast cancer

目的分析联合检测血清肿瘤相关抗原CA153、CA125、组织多肽特异性抗原（TPs）和骨桥蛋白（OPN）在乳腺癌诊断中的幄床应用价值。方法选取我院乳腺科154倒乳腺癌患者和40倒乳腺良性肿瘤患者为研究对象，所有患者全部检测血清肿瘤相关抗原（CA153、CA125、TPS、OPN），其中，CA153、CA125、TPS采用电化学发光法检测，OPN采用酶联免疫吸附试验法（EusA）检测。结果乳腺癌组与乳腺良性肿瘤组血清肿瘤相关抗原浓度比较有统计学意义（P〈0．01）,CA153、CA125、TPS、OPN诊断乳腺癌的敏感性分别为：63．O％、60．4％、68．2％、64．9％；特异性分剐为：95．O％、90．O％、92．5％、92．5％。联合检测敏感性明显提高，高达96．8％。结论联合检测血清肿瘤相关抗原可明显提高乳腺癌诊断的敏感性，减少漏诊，具有重要的临床应用价值。

Objective To explore the clinical value of the combined detection including CA153, CA125, tissue polypeptide specific anti- gen （TPS） and osteopontin （OPN） in the diagnosis of breast cancer. Methods 154 cases of breast cancer patients and 40 cases of benign breast tumor patients were selected asthe object of study. The serum tumor associated antigen CA153, CA125 and TPS were detected in dec- trochemica] luminescence method, OPN were detected in enzyme linked immunosorbent assay （ELISA）. Results The concentration of serum tumor associated antigen w!th breast cancer was compared with the one of breast benign, and the defference has statistical significance （p 〈 0. 01）, The susceptibility of CA153, CA125, TPS, OPN in the diagnosis of breast cancer were 63% ,60.4% ,68.2% and 64.9% respectively The specificity were 95% ,90% ,92.5% and 92.5%. respectively the sensitivity of the combined detection was increased significantly, up to 96.8 %. Conclusion The combined detection of serum tumor associated antigen ean obviously improve the diagnostic sensitivity of breast cancer, decrease missed diagnosis, it has important value in clinical application.