不同剂量左氧氟沙墨治疗老年下呼吸道感染的有效性和安全性临床观察

Clinical observation on efficacy and safety of different dose levofloxacin in treatment of elderly patients with lower respiratory tract infection

目的：观察分析左氧氟沙星对老年人下呼吸道感染的临床疗效，并分析其安全性。方法：回顾性分析我院2010年1月～2011年7月收治的84例老年下呼吸道感染患者，其中实验组（42例）静脉滴注左氧氟沙星，0．5g／次，1次／日；对照组（42例）静脉滴注左氧氟沙星，o．2g／次，1次／日。两组疗程均为7—14天，收集临床资料，对临床疗效和安全性进行分析和评价。结果：实验组治愈18例，有效22例，总有效率为95．24％，不良反应发生率14．29％；对照组治愈16饲，有效19例。总有效率83．33％，不良反应发生率11．9％。二组之间无显著性差异（P〉O．05）。结论：左氧氟沙星治疗老年人下呼吸道感染较为安全并且效果显著。

objective To observe efficacy and safety of levalloxacin in treatment of elderly patients with lower respiratory tract infection. Methods Retrospective analysis was performed in 84 elderly patients with lower respiratory tract infection admired in our hospital from January 2010 to July 2011. The experimental gToup （ n = 42 ） was intravenously infused with levofloxacin 0.5g, once daily, and control group （n = 42） with levofloxacin 0.2g, once daily. The duration of treatment is 7 - 14 days in both groups. Data were collected and analyzed for efficacy and safety. Results In the experimental group 18 cases were cured, and 22 cases were effective, with total effective rate of 95.24% and incidence of adverse reactions of 14.29%. In the cantrol group 16 cases were cured, and 19 cases effective, with total effective rate of 83.33% and incidence of adverse reactions of 11.9%. There were no statistical differences between the two groups （P 〉 0.05 ）. Conclusion Levofloxacin is safe and effective in treatment of the elderly with lower respiratory tract infection.