重组人凝血因子Ⅶa（rFⅦa）在创伤性凝血病中的应用
摘要
目的：观察重组人凝血因子Ⅶa（rFⅦa）在创伤性凝血病中的应用效果。方法：选11例创伤性凝血病的患者，在应用传统止血方法临床效果不明显后，改用rFⅦa（90μg／kg）单次静脉注射，观察创伤病人引流管血流量、观察凝血指标，并记录下不良反应和（或）并发症。结果：11例患者应用rFⅦa后引流管血量明显减少，与应用前引流量由1006．36±377．23ml降至330．91±128．80nd（P〈0．05）；活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）在应用rFⅦa后明显缩短（P〈0．05）；未见不良反应及血栓形成等不良反应发生。结论：rFⅦa在刨伤性凝血病中明显改善其凝血功能，纠正凝血病，有效止血。
出处
《成都医学院学报》
CAS
2012年第02Z期309-310,共2页
Journal of Chengdu Medical College
参考文献7
-
1Fresh - Frozen Plasma, Cryoprecipitate, and Platelets Administration Practice Guidelines Development Taskforce of the College of American Pathologists. Practice parameter for the use of fresh - frozen plasma, cryoprecipitate, m~d platelets. JAMA. , 1994 ;271:777 ~ 81.
-
2ROBERTS H R,MONROE D M,WHITE G C. The u of combinant factor Va in the treatment of bleeding disorders [ J ]. Blood, 2004, 104 ( 13 ) : 3 858--3 864.
-
3LEVI IM, PETERS M, BULLER H R. Efficacy and safety of recombinant factor VIa for treatment of severe bleeding : a systematic review [ J ]. Crit Care Med, 2005,33 (4) : 883--890.
-
4MEUEK K. HENDRIKS H G, DE WOLF J T,et al. Recombinant factora in orthotopic liver transplantation : influence on parameters of coagul fibrinolysis [ J ]. Blood Coagul Fihrinoysis, 2003,14 ( 2 ) : 169-174.
-
5杨圣艮,熊卫萍,李传翔,刘菁,范瑞新,郑少忆,吴若彬.基因重组凝血因子Ⅶa在心脏直视术后严重渗出血患者中的应用[J].广东医学,2009,30(8):1126-1127. 被引量：2
-
6Meng ZH, Wolberg AS, Monroe DM, et al. The effect of temperature and pH on the activity of factor VIIa : implications for the efficacy of high - dose. factor Vlia in hypothermic and acidotic patients. J Trauma. , 2003; 55:886 -9.
-
7MacLaren R, Weber LA, Brake H, et al. A multicenter assessment of recom- binant factor VIIa off- label usage : clinical experiences and associated out- comes. Transfusion 2005:45 : 1434 -42.
二级参考文献5
-
1ROBERTS H R, MONROE D M, WHITE G C. The use of recombinant factor Ⅶ a in the treatment of bleeding disorders [J]. Blood, 2004, 104(13): 3 858 -3 864.
-
2LEVI M, PETERS M, BULLER H R. Efficacy and safety of recombinant factor Ⅶ for treatment of severe bleeding: a systematic review[J]. Crit Care Med, 2005, 33(4) : 883 -890.
-
3MEUEK K, HENDRIKS H G, DE WOLF J T, et al. Recombinant factor Ⅶa in orthotopic liver transplantation: influence on parameters of coagul fibrinolysis [ J ]. Blood Coagul Fibrinolysis, 2003, 14(2): 169-174.
-
4WITIENSTEIN B, RAVN H, GOLDMAN A. Recombinant factor Ⅶ for severe bleeding during extracorporeal membrane oxygenation following open heart surgery[J]. Pediatr Crit Care Med, 2005, 6 (4) : 473 - 476.
-
5JASCHINSKI U, RIED M, LICHTWARCK ASCHOFF M, et al. Bleeding diathesis due to failed antagonism of heparin: successful treatment with recombinant factor Ⅶa [ J ]. Anesth Analg, 2004, 99(6) : 1 872.
-
1陈晓红,黄佳,王孝荣,赵志刚.重组人凝血因子[J].中国新药杂志,2006,15(19):1696-1698. 被引量：2
-
2汪勇,刘云龙.创伤性凝血病诊疗进展[J].解剖与临床,2011,16(5):432-434. 被引量：1
-
3楚鹰,郑旭文,包卿,沈文明,刘政,周培根,李瑛,卞晓星,黄琴梅,梁华平,岳茂兴.复方氨基酸联用维生素B6对创伤凝血病大鼠凝血因子表达的影响[J].中华急诊医学杂志,2016,25(5):586-591. 被引量：13
-
4师锦宁,王学文.重组活化的Ⅶ因子的临床应用[J].中国医师进修杂志,2007,30(12):68-70.
-
5周顺刚,陈方祥.重组活化Ⅶ因子在出血患者中的应用[J].重庆医学,2009,38(21):2738-2740.
-
6聆风.rF Ⅶa可能成为第一种有效治疗脑出血的药物[J].中华医学信息导报,2004,19(15):6-6.
-
7张颖影,丁宏岩.脑出血后早期血肿增大的研究进度[J].中华脑血管病杂志（电子版）,2009,3(3):34-37. 被引量：1
-
8任怡,巩芳,徐文红.重组人凝血因子Ⅶa治疗心外科术后渗血患者32例的临床分析[J].解放军药学学报,2009,25(6):553-554. 被引量：1
-
9重组因子Ⅶa对急性脑出血患者安全[J].临床荟萃,2005,20(6):321-321.
-
10王泓.重组因子Ⅶa对急性脑出血患者安全[J].中华医学信息导报,2005,20(2):8-8.
