抗真菌药物治疗外阴阴道念珠菌病敏感性的临床研究

Clinical Research of Susceptibility to Antifungal Agents in the Treatment of Vulvovaginal Candidiasis

目的探讨外阴阴道念珠菌病(VVC)的临床特征及抗真菌药物治疗VVC的敏感性。方法对我院自2008年1月至2011年8月收治的1000例妇科门诊患者的VVC发病情况进行回顾性分析,观察念珠菌对抗真菌药物的敏感性。结果通过分离1000株念珠菌,白念珠菌为610例(61%),非白念珠菌为390例(39%)。白念珠菌及非白念珠菌对氟康唑和伊曲康唑的敏感度比较差异有统计学意义(P<0.05);对酮康唑和两性霉素B的敏感度比较,差异无统计学意义(P>0.05)。结论白念珠菌是VVC的主要致病菌,非白念珠菌的药物敏感性较白念珠菌低,白念珠菌对抗真菌药物的耐药性不常见。

Objective To discuss the clinical features of vulvovaginal eandidiasis （ VVC ） and the sus- ceptibility to antifungal agents in the treatment. Methods Retrospective analysis of VVC incidence of 1000 gynecological outpatients of our hospital from January 2008 to August 2011 was done, Candida albicans sensi- tivity to antifungal agents was observed. Results Among the 1000 cases,610 patients（61% ） had Candida albieans, and 390 patients（ 39% ）had non-Candida albieans. Sensitivity of Candida albicans and non-Candi- da albicans to fluconazole and itraconazole werestatistically significantly different （ P 〈 0.05 ）. Sensitivity to ketoconazole and amphotericin was not significantly different （ P 〉 0.05 ）. Conclusion The main pathogen of VCC is Candida albicans, non-Candida albicans drug sensitivity is lower than Candida albicans, antifungal drug resistance is not common in Candida albicans.