2011年汉中市中心医院细菌耐药性监测分析

Analysis of Bacteria Antibiotic Resistance in Hanzhong Centre Hospital in 2011

目的了解2011年临床分离菌株对常用抗生素的耐药情况。方法细菌鉴定与药敏实验采用全自动细菌鉴定仪,手工鉴定系统以及纸片扩散法。实验及判读标准均按美国临床实验室标准化协会推荐的进行。结果 2011年细菌培养标本14 701例,分离菌株3643株,革兰阴性菌占71%,革兰阳性菌占29%。前5位的细菌为:大肠埃希菌、肺炎克雷伯菌、鲍曼不动杆菌、金黄色葡萄球菌、铜绿假单胞菌。其中耐药菌种大肠埃希菌产超广谱β内酰胺酶占54.7%,肺炎克雷伯菌产β内酰胺酶占50.7%,多重耐药鲍曼不动杆菌占36.40%,耐甲氧西林金黄色葡萄球菌占32.20%,多重耐药铜绿假单胞菌占7.70%。结论常见葡萄球菌、链球菌对红霉素都有较高的耐药性。分离到对万古霉素耐药的溶血葡萄球菌(5.7%)。大肠埃希菌、肺炎克雷伯菌、奇异变形杆菌都对亚胺培南保持较高的敏感性,而阴沟肠杆菌则有1%的耐药率。

Objective To investigate the antibiotic resistance status of bacteria isolated from the hospital in 2011. Methods Bacterial identification and antibiotic testing were carried out by automatic system,man- ual identification and K-B method was done according to CLSI. Results A total of 3643 bacteria were isola- ted from 14701 samples in 2011, Gram-negative bacteria accounted for 71%, Gram-positive bacteria accoun- ted for 29%. The top five were E. coli,K, pneumoniae,Acinetobacter baumannii,Staphylococcus aureus,and Pseudomonas aeruginosa. In Gram negative bacilli, ESBLs was up to 54.7%. In K. pneumoniae, ESBLs was up to 50. 7%, MDR Acinetobacter baumannii, MRSA, MDR pseudomonas aeruginosa were 36. 40%, 32.20% ,7.70%. Conclusion Common ataphylococcus and streptococcus showed a high resistance to eryth~ romycin ; Staphylococcus haemolyticus showed 5.7 % resistance to vancomycin ;E. coli ,K. pneumoniae, Proteus mirabilis showed a high susceptibility to imipenem, while enterobacter cloacae showed 1% resistance.