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天然药物鱼藤素抗肿瘤作用机制研究进展 被引量：3

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摘要 天然产物鱼藤素是近年来的研究热点之一。鱼藤素是鱼藤酮类化合物的一种，是从非洲灰毛豆叶尖部分离出的一类物质^[1]，最初作为杀虫剂广泛使用，最近几个体内外研究表明，鱼藤素很有希望成为癌症预防和治疗药物，最初报道鱼藤素具有潜在的化学预防活性是来自Pezzuto等人对乳腺癌和皮肤癌的形成过程研究发现的，随后的研究揭示了鱼藤素对多种癌细胞形成及发展具有预防和治疗作用^[2]。
作者 张先稳 卜平
机构地区 扬州大学医学院
出处 《医学研究杂志》 2012年第9期13-14,26,共3页 Journal of Medical Research
关键词 抗肿瘤作用机制 鱼藤素 天然药物 鱼藤酮类化合物 癌症预防 天然产物 治疗药物 化学预防
分类号 R979.5 [医药卫生—药品]
  • 相关文献

参考文献15

  • 1Udeani GO, Gerhauser C, Thomas CF, et al. Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid [ J ]. Cancer Res, 1997,57 ( 16 ) :3424 - 3428.
  • 2Cuendet M, Pezzuto JM. The role of cyclooxygenase and lipoxygenase in cancer chemoprevention[J]. Drug Metabol Drug Interact,2000,17 (1-4):109-157.
  • 3Chu ZH, Liang XH, Zhou XL, et al./AppData/Local/Microsoft/ Windows/Temporary Internet Files/Content. IE5/pubmedEffects of deguelin on proliferation and apoptosis of MCF - 7 breast cancer cells by phosphatidylinositol 3 - kinase/Akt signaling pathway [ J ]. Zhong Xi Yi Jie He Xue Bao,2011,9(5) :533 -538.
  • 4Thamilselvan V, Menon M, Thamilselvan S, et al. Anticancer efficacy of deguelin in human prostate cancer ceils targeting glycogen synthase kinase - 3 Wnt/p - catenin pathway [ J ]. Int J Cancer, 2011,129 (12) :2916 - 2927.
  • 5Lee H, Lee JH ,Jung KH ,et al. Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer[J]. Oncol Rep,2010,24(4) :957 -963.
  • 6Hu J, Ye H, Fu A, et al. Deguelin - an inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor - D in lung tumor model [ J ]. Int J Cancer,2010,127 ( 10 ) :2455 - 2466.
  • 7Memmott RM, Dennis PA. The role of the Akt/mTOR pathway in tobacco carcinogen - induced lung tumorigenesis[J]. Clin Cancer Res, 2010,16(1) :4 -10.
  • 8Chen Y, Wu Q, Cui GH, et al. Deguelin blocks cells survival signal pathways and induces apoptosis of HL - 60 cells in vitro [ J ]. Int J Hematol, 2009,89 (5) :618 - 623.
  • 9Oh SH, Woo JK, Jin Q,et al. Identification of novelantiangiogenic anti- cancer activities of deguelintargeting hypoxia - inducible factor - 1 ct [J]. Int J Cancer, 2008,122(1) :5 - 14.
  • 10Kim WY, Oh SH, Woo JK,et al. Targeting heat shock protein 90 overrides the resistance of lung cancer cells by blocking radiation - induced stabilization of hypoxiainducible factorlalpha[J]. Cancer Res, 2009,69 (4) : 1624 - 1632.

同被引文献38

  • 1梁锦荣.用LC和ES-MS测定鱼藤素降解产物及其稳定性[J].国外医药（植物药分册）,2005,20(2):77-77. 被引量：1
  • 2吴秋玲,陈燕,陈卫华,何静.鱼藤素对K562细胞nup98表达的影响[J].中国实验血液学杂志,2007,15(1):25-28. 被引量：3
  • 3陈卫华,陈燕,崔国惠.鱼藤素作用K562细胞TopoⅠ表达的探讨[J].中国肿瘤临床,2007,34(3):121-124. 被引量：3
  • 4Chun KH,Kosmeder JW 2nd,Sun S. Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cel s[J].Journal of the National Cancer Institute,2003.291-302.
  • 5Nair AS,Shishodia S,Ahn KS. Deguelin, an Akt inhibitor,suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression,potentiation of apoptosis, and inhibition of cel ular invasion[J].Journal of Immunology,2006,(08):5612-5622.
  • 6Bortul R,Tazzari PL,Bil i AM. Deguelin, A PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cel s with an active PI3K/Akt pathway[J].Br J H aemat ol,2005,(05):677-686.
  • 7Geeraerts B,Vanhoecke B,Vanden Berghe W. Deguelin inhibits expression of IkappaBalpha protein and induces apoptosis of B-CLL cel s in vitro[J].Leukemia:Official Journal of the Leukemia Society of America Leukemia Research Fund U K,2007,(08):1610-1618.
  • 8Yi T,Li H,Wang X,Wu Z. Enhancement radiosensitization of breast cancer cel s by deguelin[J].Cancer Biotherapy and Radiopharmaceuticals,2008,(03):355-362.
  • 9Jin Q,Feng L,Behrens C. Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin[J].Cancer Research,2007,(24):11630-11639.
  • 10wilsorl M,Derisi J,Kristensen HH. Exploring drug--induced alterations in gene expression in mycobacterium tuberculosis by microarray hybridIzation[J].Proceedings of the National Academy of Sciences(USA),1999.12833-12838.

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医学研究杂志
2012年 第9期

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