摘要
心血管疾病(CVD)一直是全球第一大死亡原因。已经有大量证据证实无论是在一级还是二级预防方面,他汀类药物都可以降低冠心病(CHD)和脑卒中的发病率和死亡率。这些证据还显示出他汀类药物还可以使其他高危的心血管疾病获益,如糖尿病、慢性肾病、慢性心功能衰竭、心律失常和外周血管疾病。目前所有心血管疾病的指南都推荐对无禁忌证的患者给予他汀治疗。本文综述了他汀类药物调脂外作用在临床应用的研究进展。
Cardiovascular disease（CVD） remains the top cause of global mortality.There is considerable evidence that supports the mortality and morbidity benefit of statin therapy in coronary heart disease（CHD） and stroke,both in primary and secondary prevention settings.Data also exist pointing to the advantage of statin treatment in other high-risk CVD conditions,such as diabetes,CKD,CHF,arrhythmias and PVD.International clinical guidelines in the management of these CVD conditions all advocate for the utilization of statin therapy in appropriate patients.The purpose of the present review is to systematically evaluate the progress of non-lipid-lowering therapy of statin in clinical practice.
出处
《中外医学研究》
2012年第28期149-153,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
心血管疾病
他汀类
冠心病
Cardiovascular disease
Statin therapy
Coronary heart disease
