糖尿病肾病不同分期证候演变研究

TCM syndrome development research of diabetic nephropathy in different stage

目的:针对糖尿病肾病(DN)早期、临床期患者,开展糖尿病肾病不同分期证候演变研究。方法:收集早期DN及临床期DN的证候学资料,进行辨证及证素的提炼,对证候及证素进行统计学分析。结果:随着病情由早期演变到临床期,体现阴虚内热,热伤气阴病机的症状逐渐减少,阳虚的症状、证素呈现逐渐增多的趋势,临床期DN湿浊证素较早期DN逐渐增多。结论:DN病机从早期到临床期呈现气阴两虚发展向阴阳两虚的趋势,血瘀等邪实的证候贯穿早期和临床期,并有加重的趋势,其中湿浊证素较早期DN明显增加。

Targeted patients with early and clinical stage diabetic nephropathy（DN） to study TCM syndrome development of diabetic nephropathy in different stage.Methods： Collected TCM syndrome data of DN in early and clinical stages for syndrome differentiation and to refine the syndrome factors.And then the syndromes and syndrome factors were analyzed statistically.Results： As the disease evolved from the early stage to the clinical stage,the symptoms for internal heat induced byYin deficiency and heat hurt Qi and Yin were decreased,while the symptoms and syndrome factors for Yang deficiency were increased.The syndrome of dampness and turbid in early stage was more than the clinical stage of DN.Conclusion： From the early stage to the clinical stage,the pathogenesis of DN is from deficiency of both Qi and Yin to deficiency of both Yin and Yang,blood stasis is thoughout the whole stages and has worsening trend.The syndrome factor dampness and turbid in early stage was more opparent than the clinical stage of DN,which was always the key pathological factors.