VEGF、TNF-α在早期强直性脊柱炎患者中的表达意义

Expression of VEGF、TNF-a in Early ankylosing spondylitis

目的:探讨血清VEGF、TNF-α在早期AS患者发病中的表达意义。方法:采用免疫学方法,检测53例早期AS患者和39名健康对照者血清中VEGF、TNF-α,进行统计学分析。结果:早期AS患者组中血清VEGF、TNF-α水平均显著高于健康对照组(P<0.05),表明VEGF、TNF-α是早期AS患者发病过程中的重要炎症指标。结论:VEGF、TNF-α是AS发病相关的细胞因子,直接或间接参与早期AS炎症的发生、血管增生及关节软骨破坏等病理过程,可以作为早期AS的实验室指标及疾病转归指标,也可以作为监测TNF-α蛋白拮抗剂用于强直性脊柱炎活动期临床疗效的观察指标。

Objective： Explore the expressing of serum VEGF, TNF-α in early AS patients . Meth- ods：by ELISA, detection of VEGF ,TNF-α level between 53 cases with Early AS and Healthy control group 39 cases, and do Statistical analysis. Results：the serum VEGF,TNF-α level of early AS patients is Significantly higher than The control group（ P 〈 0.05 ）, Show that VEGF,TNF-cds an important indicator of inflammation In the early AS patients. Conclusion：VEGF and TNF-α s a cytokine associated with AS disease, directly or indirectly involved in the early AS inflammation and Vascular proliferation and pathological processes of artic- ular cartilage destruction, Can be used in the early stage of the laboratory AS index and Disease better index, Can be used as a monitoring TNF-α protein antagonists too AS the clinical curative effect of observation AS active period index.