摘要
目的:了解医院大肠埃希菌的临床分布特点和耐药性,为合理使用抗菌药物和预防医院感染提供依据。方法:回顾性分析2008年-2011年临床标本中分离的828株大肠埃希菌资料;用WHONET5.4软件汇总其耐药率,SPSS17.0进行χ2检验。结果:大肠埃希菌标本来自尿标本最多(30.80%),以泌尿外科的检出最多(18.00%);耐药率最低的抗菌药物为美罗培南(1.81%);头孢噻肟不敏感的大肠埃希菌对各类抗菌药物的耐药率多高于敏感株。结论:大肠埃希菌对抗菌药物呈现不同程度的耐药,碳青霉烯类抗菌药仍然是活性最高的药物,但已经出现耐药菌株。而通过医院多部门、多学科共同努力,达到合理、规范的应用抗菌药物、降低耐药率是有可能的。
Objective：To investigate the clinical distribution and drug resistance of escherichia coli in hospital,so as to provide reference for rational use of antibiotics and infection control.Methods： The results of drug resistance and clinical distribution of escherichia coli from 2008 to 2011 in our hospital were analyzed;the antimicrobial resistant rates were analyzed by WHONET 5.4 and SPSS 17.0.Results： The major strains were isolated from urine（30.80%） and mainly distributed at urology surgery（18.00%）;the lowest drug resistant rates of antimicrobials were found in meropenem（1.81%）;the resistant rates of cefotaxime-susceptible escherichia coli isolates to most tested antibiotics were lower than those of cefotaxime non-susceptible strains.Conclusion： Escherichia coli present various degrees of resistance to antimicrobial agents,carbapenems remain to have the highest activity against escherichia coli,but the resistance to meropenem has appeared.Through the multidisciplinary joint effort,standardizing the antibiotics use and reducing the resistance is possible.
出处
《中国卫生检验杂志》
北大核心
2012年第9期2214-2216,共3页
Chinese Journal of Health Laboratory Technology
关键词
大肠埃希菌
临床分布
耐药性
Escherichia coli
Clinical distribution
Drug resistance
