摘要
目的:研究和监测结核分枝杆菌不同药物浓度下耐药情况,为临床合理用药提供依据。方法:采用绝对浓度间接法,对利福喷丁、异烟肼、对氨基水杨酸、链霉素、吡嗪酰胺、乙胺丁醇、利福平、丁胺卡那、帕司烟肼、丙硫异烟胺、卷曲霉素、氧氟沙星12种药物的药敏试验。结果:223例肺结核患者痰分枝杆菌标本中,总耐药率为93.72%、其中初治患者为92.54%,复治为95.51%;单耐药率为10.31%;耐多药率为37.22%,初治为28.36%,复治为50.56%;广泛耐药率8.07%,约占耐多药的21.69%。结论:结核分枝杆菌培养在不同浓度下进行结核药敏试验,可以科学、合理地指导临床用药。
Objective：To study and monitor the drug resistance of mycobacterium tuberculosis at different concentrations,ao as to provide basis for the rational drug use in clinic.Methods： With absolute concentration method,Rifapentine,Isoniazid,Para-aminosalicylic acid,Streptomycin,Pyrazinamide,Ethambutol,Rifampin,Amikacin,Pasiniazid,Prothionamide,Capreomycin and Levofloxacin were conducted susceptibility test.Results： In 223 sputum specimens of Mycobacterium tuberculosis patients,the total drug resistance rate was 93.72%,patients with early treatment（92.54%）,retreated patients（95.51%）;single drug resistance rate（10.31%）,MDR rate（37.22%）,initial treatment（28.36%）,retreated patients（50.56%）;Extensively drug-resistance rate（8.07%）,accounting for 21.69% of MDR.Conclusion： Mycobacterium tuberculosis drug susceptibility test at different concentrations can guide scientific and rational use of drugs in clinic.
出处
《中国卫生检验杂志》
北大核心
2012年第9期2222-2224,共3页
Chinese Journal of Health Laboratory Technology
关键词
分枝杆菌
结核
浓度
耐药
Mycobacterium
Tuberculosis
Concentration
Drug resistance
