摘要
1例28岁女性患者因系统性红斑狼疮静脉滴注甲泼尼龙40 mg,1次/d。第5天加用环磷酰胺(CTX)0.8 g静脉滴注,并辅以水化治疗及碱化尿液。加用CTX第2天,患者出现肉眼血尿。尿沉渣3 h计数:红细胞163万/h,均一型红细胞90%,膀胱镜检查示膀胱黏膜出血。考虑为环磷酰胺所致出血性膀胱炎。继续使用甲泼尼龙、给予酚磺乙胺,并予充分水化治疗、碱化尿液。3 d后肉眼血尿消失。2周后复查尿沉渣正常。15 d后患者再次接受CTX冲击治疗,同时静脉滴注美司钠及接受水化治疗、碱化尿液,未再发血尿。
A 28-year-old female patient receive an IV infusion of methylprednisolone 40 mg once daily for systemic lupus erythematosus.On day 5,an IV infusion of cyclophosphamide 0.8g was added to the regimen,at the same time she was given hydration therapy and urinary alkalinization.The next day,she developed gross hematuria.Her urinary sediment counting for 3 hours revealed 1.63×106 RBCs/hour with 90% isomorphic RBCs.Cystoscopy revealed hemorrhage of bladder mucosal.Hemorrhagic cystitis induced by cyclophosphamide was considered.Methylprednisolone was continued,and she received etamsylate,adequate hydration therapy and urinary alkalinization.Gross hematuria disappeared after 3 days.Two weeks later,a repeat urine sediment examination was normal.Fifteen days later,the patient was retreated with cyclophosphamide pulse therapy and,at the same time,she was given an IV infusion of mesna,hydration therapy and urinary alkalinization.Hematuria did not reappear.
出处
《药物不良反应杂志》
2012年第4期251-252,共2页
Adverse Drug Reactions Journal
关键词
环磷酰胺
膀胱炎
cyclophosphamide
cystitis
