二莲汤辅助治疗Ⅲ期直肠癌40例

Clinical Observation of Chinese Medicine Erlian Decoction Adjuvant Treatment of Stage Ⅲ Colorectal Cancer

目的观察中药"二莲汤"治疗Ⅲ期直肠癌的疗效与毒副作用。方法遴选80例Ⅲ期直肠癌患者,随机分为观察组与对照组各40例。观察组采用中药"二莲汤"灌洗联合同步放化疗,对照组采用单纯放化疗,方案:奥沙利铂(L-OHP)130mg/m2+5%GS500ml静滴2h,d1;亚叶酸钙(CF)100mg/m2+5%GS250ml静滴1h,d1～5;氟尿嘧啶(5-Fu)500mg/m2+5%GS1000ml静滴4h,d1～5,共化疗1周期。放射剂量为60～70Gy。结果观察组总有效率为67.5%,对照组为45%,2组比较有统计学意义(P<0.05)。在毒副作用方面,观察组明显低于对照组(P<0.05)。观察组生活质量提高为60%,对照组提高为33.3%(P<0.05),2组比较差异有统计学意义。结论中药"二莲汤"辅助治疗Ⅲ期直肠癌,可以一定程度减轻放化疗的毒副作用,提高患者的生存质量。

Objective To observe the traditional Chinese medicine ／＂two Ephraim soup／＂ in the role of Ⅲ colorectal cancer curative effect and the side effects.Methods 80 cases of Ⅲ selection of colorectal cancer patients were randomly divided into observation group and the control 40 cases.The observation group 40 cases by the Chinese medicine ／＂two Ephraim soup／＂ known as irrigation joint chemoradiation,40 cases of control group,the simple concurrent chemoradiation,plan：oxaliplatin into（L-OHP） 130 mg /m2 ＋ 5% GS500ml static drops 2 h,d1,;The folic acid calcium（CF） 100 mg /m2 ＋ GS250ml static drops 1 h,d1 ～ 5;Fluorouracil（5 its） 500 mg /m2 ＋ 1000 ml static drops 4 h,d1 ～ 5,total chemotherapy 1 cycle.The radiation dose for 60 ～ 70 Gy.Results The observation group the total effective rate was 67.5%,and the control group only 45%,two groups of comparisons are statistically significant（P〈0.05）.In the side effects,the observation group was significantly lower than the control group（P〈0.05）.The observation group to enhance the quality of life is 60%,and the control group increased by 33.3%（P〈0.05） two groups of comparisons are statistically significant differences.Conclusion Chinese medicine ／＂two Ephraim soup／＂ Ⅲ auxiliary treatment of colorectal cancer,can reduce a certain degree the side effects of radiation and chemotherapy,improve the quality of life of the patients.