紫杉醇方案治疗晚期食管癌的临床研究进展

Clinical research progress on paclitaxel in the treatment of advanced esophageal cancer

食管癌由于其相对较高的发病率及死亡率,危害日益突出,故对食管癌治疗的研究具有显著的意义。大多数病人就诊时已是局部不可切除或远处转移,由于缺乏有效的治疗控制疾病进展,转移或复发的食管癌是不可治愈的,且预后差。探索紫杉醇最佳剂量及方案是降低毒副反应同时实现抗肿瘤活性的关键之处。

Due to the high incidence and mortality of digestive system malignant tumor, it is of great significance to make further research for digestive tract tumor. The majority of patients having poor diagnosis is local advanced or distant metastasis esophageal cancer while in itial visit, Metastatic esophageal carcinoma is an incurable disease and has poor prognosis, due to the lack of effective therapies to man age this disease. Identifying an optimal dose and schedule for paclitaxel therapy is key to minimizing toxicity while maintaining antitumor acttvlty