摘要
核因子kappa B(NF-κB)是一种重要的转录因子,NF-κB能够调节诸多基因的表达,参与炎症、免疫应答、细胞增殖、细胞凋亡等生物过程。肠道的缺血再灌注损伤是一种常见的病理生理过程,研究表明许多细胞因子参与了这一过程,如TNF-α、IL-1、IL-6、ICAM-1等,而NF-кB可以调控这些因子的表达。现就NF-κB和肠缺血再灌注损伤之间的联系和作用作一综述。
Nuclear factorkappa B （NFKB） is a key transcriptional regulator. It can regulate the expression of several target genes in volved in inflammation, the immune response, cell survival, proliferation and apoptosis. Intestinal ischemia/repeffusion injury was wide ly reported to be a common pathophysiologie process involved by many cytokines, such as TNFc~, IL1, IL6 and ICAM1 etc. But NFKB can regulate their expression. This paper reviewed the role of NFKB pathway in intestinal ischemia/reperfusion injury.
出处
《安徽医药》
CAS
2012年第11期1564-1565,共2页
Anhui Medical and Pharmaceutical Journal
基金
安徽省自然科学青年基金资助项目(No 11040606Q21)
关键词
核转录因子ΚB
缺血/再灌注损伤
肠道
nuclear factor-kappa B
ischemiafreperfusion injury
intestinal
