非布司他主要杂质的合成与结构鉴定

Synthesis and identification of the main impurity of febuxostat

目的研究非布司他主要杂质的结构和产生的原因。方法和结果用HPLC法分离该杂质,用波谱法推导其结构,再用合成制备对其结构进行确证。结论该杂质的结构为2-(3-羟基亚胺甲基-4-异丁氧苯基)-4-甲基噻唑-5-羧酸。

Objective To identify the structure and source of the main impurity of febuxostat. Methods ＆ Results The main impurity was separated by HPLC and its structure was identified by spectroscopy and chemical synthesis. Conclusion The main impurity of fe- buxostat was confirmed as 2- （ 3- （ （ hydroxyimino ） methyl ） -4-isobutoxyphenyl ） -4-methyhhiazole-5-carboxylic acid.