原发性肝癌手术切除联合TACE与单纯手术切除疗效对比分析

A comparative study between surgery and combined surgery with TACE in the therapy of PHC

目的探讨术后预防性肝动脉栓塞化疗(TACE)对原发性肝癌患者生存率及肿瘤复发率的影响。方法回顾性分析2005年1月—2009年6月期间105例在我院临床诊断为原发性肝癌并接受根治性切除手术患者的临床资料。其中手术后行TACE组50例,单纯手术组55例。对两组患者术后1、2、3年生存率及肿瘤复发率进行比较。结果手术联合TACE组与单纯手术组比较,前者的患者1、2年的生存率明显高于后者(P<0.05),前者的1、2年的复发率明显低于后者(P<0.05),但两组第三年的生存率及复发率无显著差异(P>0.05)。结论对原发性肝癌患者手术后行TACE治疗可明显降低低近期肿瘤复发率且显著提高患者的生存率。

Objective To explore the effects on the patients＇ survival rate and tumor recurrence rate of TACE after hepatectomy for PHC. Methods Retrospective analysis was made of date January 2005 to June 2009 in our hospital. A hundred and five patients with PHC were studied in this research. TACE was performed in 50 patients from after operation but not in the other 55 patients. The postoper ative recurrence rate of the tumors and the survival rate of the patients were compared between the two groups. Results In TACE group, the tumor recurrence rate within one year and two years after operation was remarkably lower than that of the other group （ P 〈 0.05 ）. In TACE group, the patients＇ survival rate within one year and two years after operation was remarkably higher than that of the other group（P 〈 0.05）. But in the two groups survival rate and the recurrence rate of the third year had no significant difference （P 〉 0.05 ）. Conclusion TACE after operation could remarkably decrease the tumor recurrence rate and increase postoperative survival rate.