TBX2在甲状腺癌组织中的表达及其临床意义

Expression and clinical significance of TBX2 in thyroid carcinoma

目的:检测TBX2在甲状腺癌组织中的表达,探讨其临床意义。方法:应用RT-PCR方法检测TBX2在9例正常甲状腺、13例甲状腺腺瘤及67例甲状腺癌组织(其中甲状腺乳头状癌28例,甲状腺滤泡癌23例,甲状腺髓样癌14例,甲状腺未分化癌2例)中的表达。结果:TBX2mRNA在甲状腺癌组织中的阳性表达(阳性表达56例,占83.6%)明显高于其在正常甲状腺(阳性表达3例,占33.3%)及甲状腺腺瘤组织(阳性表达6例,占46.2%)中的阳性表达(P<0.05),差异有显著性;TBX2mRNA在甲状腺乳头状癌、甲状腺滤泡癌及甲状腺髓样癌(甲状腺未分化癌例数太少,无统计学意义)组织中的阳性表达强度(相对系数)分别为1.776±0.382、2.627±0.532、2.937±0.481;P<0.05,差异具有显著性。TBX2mRNA在甲状腺癌组织中的阳性表达强度与甲状腺癌组织的分化程度及组织学分型有关。结论:TBX2可能是甲状腺癌发生、发展的促进因子,并有可能成为甲状腺癌临床诊断及预后评估的又一重要参考指标。

Objective：To detect the expression of TBX2 in thyroid carcinoma and investigate clinical significance.Methods：The expression of TBX2 was detected in 9 normal thyroids,13 thyroid adenomas and 67 thyroid carcinomas（including 28 thyroid papillary carcinomas,23 thyroid follcular carcinomas 14 medullary thyroid carcinomas and 2 undifferentiated thyroid carcinomas） by using RT-PCR.Results：TBX2mRNA had a high positive expression in thyroid carcinoma（there was positive in 56 cases,83.6%） which was significantly different with the expression in normal thyroid tissue（there was positive in 3 cases,33.3%） and thyroid adenoma（there was positive in 6 cases,46.2%）（P0.05）.The positive expression intensity（relative coefficient） of TBX2mRNA in the thyroid papillary carcinoma,thyroid follcular carcinoma and medullary thyroid carcinoma was 1.776±0.382、2.627±0.532、2.937±0.48,respectively（P0.05）.Its expression intensity was related to the differentiation of thyroid carcinoma and type of histology（P0.05）.Conclusion：TBX2 is possible enhancing factor of thyroid carcinogenesis occurrence and development,and is possible another important reference index of clinical diagnosis and prognosis evaluation of thyroid carcinoma.