润燥止痒胶囊联合甘草酸二铵治疗面部激素依赖性皮炎患者的疗效及相关免疫学分析

Efficacy and Immunological Analysis of Combined Runzao Itching Capsules with Diammonium Glycyrrhizinate on Treating Facial Corticosteroid Addictive Dermatitis

目的探讨润燥止痒胶囊联合甘草酸二铵治疗方案对面部激素依赖性皮炎(facial corticosteroid addictive dermatitis)患者免疫水平的影响。方法本研究组选择面部激素依赖性皮炎患者68例,采用润燥止痒胶囊口服(4片/次,3次/d)联合甘草酸二铵静脉滴注(150 mg/次,1次/d),在此基础上,3%硼酸溶液冷湿敷面部,每次15～30 min,连续治疗6周为1个疗程,治疗前、2周、4周后对机体免疫球蛋白水平进行检测,并对临床效果进行评估分析。结果治疗1个疗程后,患者症状评分较治疗前明显降低(t=4.73,P<0.01),临床总有效率为92.65%;治疗后血清白细胞介素(interleukin-4,IL-4)水平呈下降趋势,4周后与治疗前相比较明显降低(t=9.81,P<0.05),血清总免疫球蛋白E(immunoglobulin E,IgE)水平明显降低(t=3.89,P<0.05),IgG、IgA、IgM与治疗前相比较均具有统计学意义(P<0.01)。结论润燥止痒胶囊联合甘草酸二铵治疗面部激素依赖性皮炎,疗效满意,其机制可能与机体免疫调节有关。

Objective To investigate effect on the level of immunity in patients who used the Runzao itching capsules and diammonium glycyrrhizinate to treat facial corticosteroid addictive dermatitis.Methods 68 patient in study group were taken Runzao itching capsules three times a day（four pills per time） and intravenous injection with diammonium glycyrrhizinate everyday（150 mg per day）.Then,3% boric acid was used to wet pack the face（15-30 min per time）.A course was six weeks.The level of immunoglobulin was detected before treatment,after two and four weeks,and than clinical effect was evaluated.Results After a course,the score of the symptom continued to decline（t=4.73,P 0.01）.Clinical total effective rate was 92.65%.There was a downward trend in the level of IL-4.After four weeks,score of the symptom was decreased（t=9.81,P0.05）and the immunoglobulin E（IgE） was decreased obviously（t=3.89,P0.05）.IgG,IgA and IgM had statistically significant difference after treatment（P0.01）.Conclusion We have a satisfied result in using Runzao itching capsules and diammonium glycyrrhizinate for treating facial corticosteroid addictive dermatitis.Its mechanism may have relationship with the immune regulation.