新疆乌鲁木齐汉族、维族骨量减少女性骨生化标志物和维生素D水平的研究

Study of bone biochemical markers and vitamin D level in Han and Uygur women with osteopenia in Urumqi

目的通过分析新疆乌鲁木齐地区汉族与维吾尔族骨量减少女性之间骨生化标志物和维生素D的水平,探讨维吾尔族骨量减少的特点。方法选择2008年5月至2011年3月期间,我院就诊的骨量减少的女性500例,其中汉族306例(61.2%),维族194例(38.8%),对比分析两组体重指数、血清电解质、部分骨生化标记物以及25羟基维生素D水平。结果两组平均年龄、体重指数、血清Ca、P、Mg水平无统计学差异(P>0.05);骨特异性碱性磷酸酶(BAP)无显著性差异(P>0.05);骨钙素(BGP)、抗酒石酸酸性磷酸酶5b(TRACP-5b)水平,维吾尔族高于汉族组(P<0.05);汉族各年龄阶段VitD水平均高于维吾尔族,具有统计学显著性差异。结论骨转换水平较高和VitD缺乏在维吾尔族女性骨量减少中发挥着重要的作用。

Objective To study the characteristic of Uygur women with osteopenia by analyzing the biochemical markers of bone turnover and vitamin D between Uygur and Han in Urumqi. Methods Five hundred women who were diagnosed as osteopenia in our hospital from May 2008 to Mar 2011 were included in this study. Among those, 306 women were Han and 194 were Uygur. Body mass index （BMI） , serum electrolytes, bone biochemical markers, and 25-hydroxy vitamin D were analyzed and compared between Han and Uygur groups. Results There were no significant differences in BMI, serum Ca, P, Mg levels, and bone specific alkaline phosphatase （BAP） between the two groups （P 〉 0.05 ）. The levels of bone gamma- carboxyglutamieacid-containing proteins （BGP） and tartrate-resistant acid phosphatase 5b （TRACP-5b） in Uygur patients were significantly higher than those in Han patients （ P 〈 0.05 ）. The level of 25-hydroxy vitamin D （25-（OH）-Vit D） in Han group was significant higher than that in Uygur group （P 〈 0.05 ）. Conclusion High level of bone turnover and 25 - （OH） - Vit D deficiency plays an important role in the process of osteopenia in Uygur women.