成都地区健康人群髋部骨密度及几何参数变化的初步研究

The preliminary study of bone mineral density and geometry parameters of the hip in healthy people in Chengdu

目的观察成都地区健康人群股骨近端骨密度及几何参数的变化。方法用美国GE LUNAR公司生产的Prodigy advance测定成都地区健康人群4121例,其中男例2271例,女1850例,年龄20～96岁。测量部位包括左股骨颈(Neck)、大转子(Troch)、Wards区、股骨干(Shaft)、全髋(Total)骨密度,并计算几何参数:髋轴长度(HAL)、横断面转动惯量(CSMI)、横截面积(CSA)、颈干角(NSA)、髋部强度指数(FSI)。按年龄、性别分别输入数据,以10岁为一年龄组,分别计算各组骨密度及几何参数值;结果用spss14.0统计软件处理。结果 1.男性髋部骨密度峰值出现在20～29岁,女性骨密度峰值出现在30～39岁。同年龄组女性骨密度累积丢失率明显高于男性。2.男性CSMI峰值在30～39岁,CSA峰值在20～29岁,随年龄增加逐渐降低。女性CSMI、CSA、SI峰值在20～29岁,随着年龄增加逐渐降低。3.男、女HAL与年龄、BMI、股骨各部位骨密度呈弱相关性,与身高、体重呈正相关。男、女CSMI、CSA与身高、体重、股骨骨密度呈正相关。男、女NSA、SI与骨密度呈正相关。结论 1.本组健康人群股骨骨密度、几何参数为成都地区骨质疏松防治提供参考依据;2.随年龄增长伴随骨密度丢失和几何参数变化,以女性更为明显;3.女性更应注意骨质疏松的防治。

Objective To investigate the changes of bone mineral density （BMD） and geometry parameters of the proximal femur in healthy people in Chengdu. Methods A total of 4121 healthy people （2271 men and 1850 women） from 20 to 96 years old were measured with dual energy X-ray absorptiometry （DXA, GE LUNAR, USA）. The measured location included the left femoral neck, the Troch area, the Ward＇s area, the shaft of the femur, and the total hip. Hip DXA images were used to calculate BMD and geometry parameters, including hip axis length （HAL）, cross-sectional moment of inertia （CSMI）, cross-sectional area （CSA） , neck-shaft angle （NSA） , and femur strength index. （FSI）. People were divided into 10-year subgroups. The results were analyzed with SPSS 14.0. Results 1 ） The peak BMD in men and women presented in the group of 20 - 29 and 30 - 39, respectively. The accumulative bone loss percentage in females was much higher than that in males in the same age group. 2） In men, peak values of CSMI and CSA were observed at the age of 30 - 39 years and 20 - 29 years, respectively. Both CSMI and CSA decreased with age in men. In women, the peak values of CSMI, CSA and FSI appeared at the age of 20 - 29 and declined with age increasing. 3） HAL showed positive correlation with height and weight, and weak correlation with age, BMI, and BMD, both in men and women. CSMI and CSA were positively correlated with height, weight, and BMD of the proximal femur in both sexes. NSA and FSI were positively correlated with BMD both in men and women. Conclusion 1 ） The data of BMD and geometry parameters of the proximal femur provide references for the diagnosis and treatment of osteoporosis in Chengdu. 2） BMD loss and geometry parameter change are more evident in women with aging. 3） Women should pay more attention to the prevention and treatment of osteoporosis.