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BMPs及其相关microRNAs在MSC向成骨细胞分化过程中的作用 被引量：2

The role of BMPs and related microRNAs in osteoblast differentiation by MSCs
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摘要 目的间充质干细胞(MSCs)向成骨细胞分化是目前组织工程和骨愈合研究的热点。已有大量文献报道骨诱导形成蛋白(BMP)在该过程中的作用,随着微小RNA(microRNA,miRNA)的发现,其对BMP在MSC向成骨细胞诱导分化过程中所起的调控作用也日益受到重视。作者归纳总结了BMPs及其相关miRNA在MSC向成骨细胞分化过程中的作用,以及一些常用生物材料在诱导MSCs向成骨细胞分化过程中,对BMP及相关miRNA的影响。为进一步的研究提供了借鉴和参考。 The osteoblast differentiation from mesenchymal stem cells （MSCs） is a hotspot in tissue engineering and bone healing research currently. Numerous literatures has reported that bone morphogenetie protein （BMP） plays an important role in this process. Many miRNAs have been found to participate into this process by regulating the function of BMPs. In this review, we present the related references in recent years to summarize the role of BMP and miRNAs in this process. The research of biomaterial which is associated with the regulation of miRNAs and BMPs in this process has also been included.
作者 康夏 权毅 董世武
机构地区 第三军医大学解剖学教研室生物力学实验室 成都军区总医院骨科
出处 《中国骨质疏松杂志》 CAS CSCD 北大核心 2012年第9期846-849,共4页 Chinese Journal of Osteoporosis
基金 国家重点基础研究发展计划项目(2011CB964701) 国家自然科学基金项目(31070864)
关键词 间充质干细胞 MICRORNAS 成骨分化 骨形成蛋白 Mesenchymal stem cell （MSC） MicroRNAs Osteogenesis Bone morphogenctic protein （BMP）
分类号 R681 [医药卫生—骨科学]
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参考文献30

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同被引文献27

  • 1郑军,齐新生.骨形态发生蛋白在骨缺损和坏死修复中的成骨机制和运用[J].中国矫形外科杂志,2004,12(23):1888-1890. 被引量：6
  • 2Pham L, Beyer K, Jensen ED, et al. Bone morphogenelic protein 2 signaling in osteoclasts is negatively regulated by the BMP antagonist, twisted gastrulation[J]. J Cell Biochem, 2011,112(3):793-803.
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  • 5Rui YF, Lui PP, Lee YW, et al. Higher BMP receptor expression and BMP-2-induced osteogenic differentiation in tendon-derived stem cells compared with bone-marrow-derived mesenchymal stem cells[J]. Int Orthop, 2012,36(5): 1099-1107.
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  • 7Bajzova M, Kov-tcikovfi M, Vitkovfi M, et al. Retinol-binding protein 4 expression in visceral and subcutaneous fat in human obesity [J]. Physiol Res,2008,57(6):927-934.
  • 8Stefan N, Hermige AM, Staiger H, et al. High circulating retinol- binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans[J]. Diabetes Care, 2007,30(5): 1173-1178.
  • 9Munkhtulga L, Nagashima S, Nakayama K, et al. Regulatory SNP in the RBP4 gene modified the expression in adipocytes and associated with BMI[J]. Obesity(Silver Spring), 2010,18(5): 1006-1014.
  • 10Kotnik P, Fischer-Posovszky P, Wabitsch M. RBP4: a controversial adipokine[J]. Euro J Endocrinol, 2011,165(5):703-711.

引证文献2

二级引证文献7

中国骨质疏松杂志
2012年 第9期

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