小牛血清去蛋白肠溶胶囊治疗小儿热性惊厥后脑损伤的疗效及安全性观察

Efficacy and safety of deproteinised calf blood enteric capsules in treatment of children with febrile convulsions and brain damage caused by repeated febrile seizure

目的观察小牛血清去蛋白肠溶胶囊治疗小儿热性惊厥及惊厥后脑损伤的疗效及安全性。方法门诊就诊的热性惊厥患儿112例,随机分为试验组和对照组。所有患儿均采用抗生素控制原发感染,采取对症处理控制惊厥;试验组在对症治疗的基础上加用小牛血清去蛋白肠溶胶囊,每次1粒,每日3次口服,连续使用2周。观察惊厥复发次数、脑电图改变、复发惊厥的平均持续时间以及各组患者的生命体征。结果试验组热惊厥复发率、复发惊厥持续时间以及治疗后1周和2周的脑电图异常率明显低于对照组。结论小牛血清去蛋白肠溶胶囊联合对症治疗能够有效降低小儿热性惊厥复发,并降低热惊厥导致的脑损伤,无不良反应。

Objective To study the efficacy and safety of deproteinised calf blood enteric capsules in treatment of children with febrile convulsions and brain damage caused by repeated febrile seizure. Methods 112 cases of out-patient children with febrile convulsion,were randomly divided into test and control groups. All the patients were using antibiotics to control primary infection,and taking symptomatic treatment to control seizures;in test group,patients were using DCBEC additionally,based on the symptomatic treatment, capsule usage：orally before meals,1 tablet each time,three times a day,a course of 14 days. The numbers of seizures recurrence,EEG changes,the average duration of recurrence of seizures,and the vital signs of patients in each group were observed and compared. Results In test group,the febrile convulsion recurrence rate,the duration of recurrence of seizures,abnormal EEG rate in both one and two weeks after treatment,were significantly lower than the control group. Conclusion DCBEC combined with symptomatic treatment can effectively reduce the recurrence of febrile convulsions in children,and could lighten brain damage caused by febrile convulsions,no adverse reactions.