期刊文献+

Linking innate and adaptive immunity

Linking innate and adaptive immunity
原文传递
导出
摘要 The evolution of mechanisms to fight pathogens in plants and animals is reflected in the complexity of the components of their so-called immune systems. Higher vertebrates have The evolution of mechanisms to fight pathogens in plants and animals is reflected in the complexity of the compo- nents of their so-called immune systems. Higher vertebrates have evolved two different ways to protect themselves against infectious pathogens [1]. The first is termed innate immunity and is mediated by non-clonatly distributed re- ceptors, which can also be found in plants with less com- plexity, while the second is termed adaptive immunity using clonally distributed receptors. It is thought that adaptive immunity is evolutionarily conserved and is present in or- ganisms from early evolutionary periods, such as the am- phioxus [2-4]. Because of the diversity of clonally distrib- uted receptors, including T cell receptors and immunoglob- ulins, the adaptive immune system is capable of the precise recognition of almost all biological structures. In contrast, the innate immune system is mediated by pattern recogni- tion receptors, such as Toll-like receptors (TLR),
出处 《Chinese Science Bulletin》 SCIE EI CAS 2012年第31期4100-4102,共3页
  • 相关文献

参考文献12

二级参考文献359

  • 1LIN YuShuang,CHEN DongYan,FAN QiuSheng & ZHANG HongWei Institute of Developmental Biology,Life Science College,Key Lab of Experimental Teratology of Ministry of Education,Shandong University,Jinan 250100,China.Characterization of SoxB2 and SoxC genes in Amphi-oxus (Branchiostoma belcheri):Implications for their evolutionary conservation[J].Science China(Life Sciences),2009,52(9):813-822. 被引量:4
  • 2Brass A L, Huang I C, Benita Y, et al. The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell, 2009, 139(7): 1243-1254.
  • 3Hailer O, Kochs G, Weber F. Interferon, Mx, and viral countermeasures. Cytokine Growth Factor Rev, 2007, 18 (5-6): 425-433.
  • 4MacMicking J D. IFN-inducible GTPases and immunity to intracellular pathogens. Trends Immunol, 2004, 25(11): 601-609.
  • 5Hailer O, Stertz S, Kochs G. The Mx GTPase family of interferon-induced antiviral proteins. Microbes Infect, 2007, 9(14-15): 1636-1643.
  • 6Hailer O, Staeheli P, Kochs G. Interferon-induced Mx proteins in antiviral host defense. Biochimie, 2007, 89(6-7): 812-818.
  • 7Sadler A J, Williams B R. Interferon-inducible antiviral effectors. Nat Rev Immunol, 2008, 8(7): 559-568.
  • 8Cao B, Liu X, Hou F, et al. The haplotype of the MxA gene promoter is associated with hepatitis B virus infection in a Chinese population. Liver Int, 2009, 29(9): 1383-1388.
  • 9Robertsen B. Expression of interferon and interferon-induced genes in salmonids in response to virus infection, interferon-inducing compounds and vaccination. Fish Shellfish Immunol, 2008, 25(4): 351-357.
  • 10Turan K, Mibayashi M, Sugiyama K, et al. Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome. Nucleic Acids Res, 2004, 32(2): 643-652.

共引文献69

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部