原发性高血压患者肾动脉阻力指数与超敏C反应蛋白的相关性

Correlation of renal resistive index and high-sensitive C-reactive protein in patients with essential hypertension

目的:探讨原发性高血压患者肾动脉阻力指数(renal resistive index,RRI)与超敏C反应蛋白(high-sensitiveC-reactive protein,hs-CRP)的相关性。方法:原发性高血压患者82例,应用彩色多普勒超声测量RRI,据RRI分为A组(RRI≥0.7,n=34)和B组(RRI<0.7,n=48),彩超检查当天测量收缩压(SBP)、舒张压(DBP),计算脉压(PP)、平均血压(MBP),检测肌酐、尿素氮等生化指标,免疫比浊法测hs-CRP,分析两组间各指标的差异。结果:A组年龄、PP、SBP及hs-CRP水平都明显高于B组(均P<0.01),直线相关分析显示,RRI同hs-CRP呈正相关(P<0.01)。结论:原发性高血压患者RRI与hs-CRP水平相关。

AIM： To explore the correlation of renal resistive index （RRI） and high-sensitive C-reactive protein （hsCRP） in patients with essential hypertension. METHODS： Eighty-two patients with primary hypertension were selected and RRI was detected in all cases by color Doppler flow imaging. The patients were divided into group A （RRI≥0. 7, n =34） and group B （RRI 〈0. 7, n =48） according to RRI, systolic blood pressure （SBP） and diastolic blood pressure （DBP） measured on the same day of the examination. Pulse pressure （PP） and mean blood pressure （MBP） were calculated. Blood urea nitrogen （BUN） and serum creatinine （Scr） were measured, hsCRP was measured with immunoturbidimetric assay. All results were compared between groups. RESULTS： Age, PP, SBP and hsCRP levels in group A were obviously higher than those in group B （P 〈 0.01 ）. Linear correlation analysis showed that RRI and hsCRP were positively correlated. CONCLUSIONS： RRI is related to early renal hemodynamic changes. Higher levels of hsCRP may be one reason for the intrarenal hemodynamic changes in primary hypertension patients with early renal damage